ReviewClinical ophthalmology (Auckland, N.Z.)2016
Optimal management of idiopathic macular holes.
Review in Clinical ophthalmology (Auckland, N.Z.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 73 citations in OpenAlex.
- Macular hole closure patterns associated with different internal limiting membrane flap techniques.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Trial
- Visual and anatomical outcomes of full-thickness macular hole surgery and associated factors in selected hospitals in Tanzania.PloS one · 2026Article
- Amniotic Membrane Coverage for Intractable Large Macular Holes: A First Report with Japanese Patients.Journal of clinical medicine · 2025Article
- Safety and efficacy of human amniotic membrane plug transplantation in cases of macular hole. A scoping review.International journal of retina and vitreous · 2024Article
- Topographic analysis of retinal and choroidal vascular displacements after macular hole surgery.Scientific reports · 2024Article
- Wound Healing in a Porcine Model of Retinal Holes.Investigative ophthalmology & visual science · 2024Article
- Analysis of the progression rate of idiopathic macular holes and the optimal cut-off for baseline minimum linear diameter and base diameter.Japanese journal of ophthalmology · 2024Article
- Mechanical Disruption of the Inner Limiting Membrane In Vivo Enhances Targeting to the Inner Retina.Investigative ophthalmology & visual science · 2023Article
- The effect of ethnicity on anatomic success following macular hole surgery: a multicentre cohort study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Impact of Race and Ethnicity on Presentation and Surgical Outcomes of Idiopathic Macular Holes.Journal of personalized medicine · 2022Article
- Comparison of retinal vascular arcade trajectory between eyes with an idiopathic macular hole and the healthy fellow eye.International ophthalmology · 2022Article
- Comments on: Internal Limiting Membrane Peeling and Gas Tamponade for Full-Thickness Macular Holes of Different Etiology - Is It Still Relevant? [Letter].Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Predicting the individual probability of macular hole closure following intravitreal ocriplasmin injections for vitreomacular traction release using baseline characteristics.Scientific reports · 2021Article
- Face-Down Posture versus Non-Face-Down Posture following Large Idiopathic Macular Hole Surgery: A Systemic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
- Displacement of the retina after idiopathic macular hole surgery with different internal limiting membrane peeling patterns.International journal of ophthalmology · 2021Article
- Macular Hole Detection Using a New Hybrid Method: Using Multilevel Thresholding and Derivation on Optical Coherence Tomographic Images.Computational intelligence and neuroscience · 2021Article
- Factors affecting anatomical and visual outcome after macular hole surgery: findings from a large prospective UK cohort.Eye (London, England) · 2021Article
- Efficacy of Pars Plana Vitrectomy with Internal Limiting Membrane Peeling for Treatment of Large Idiopathic Full-Thickness Macular Holes.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Rate of progression of idiopathic full-thickness macular holes before surgery.Eye (London, England) · 2020Observational
- Functional evaluation with microperimetry in large idiopathic macular holes treated by a free internal limiting membrane flap tamponade technique.BMC ophthalmology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review evaluates the current surgical options for the management of idiopathic macular holes (IMHs), including vitrectomy, ocriplasmin (OCP), and expansile gas use, and discusses key background information to inform the choice of treatment. An evidence-based approach to selecting the best treatment option for the individual patient based on IMH characteristics and patient-specific factors is suggested. For holes without vitreomacular attachment (VMA), vitrectomy is the only option with three key surgical variables: whether to peel the inner limiting membrane (ILM), the type of tamponade agent to be used, and the requirement for postoperative face-down posturing. There is a general consensus that ILM peeling improves primary anatomical hole closure rate; however, in small holes (<250 µm), it is uncertain whether peeling is always required. It has been increasingly recognized that long-acting gas and face-down positioning are not always necessary in patients with small- and medium-sized holes, but large (>400 µm) and chronic holes (>1-year history) are usually treated with long-acting gas and posturing. Several studies on posturing and gas choice were carried out in combination with ILM peeling, which may also influence the gas and posturing requirement. Combined phacovitrectomy appears to offer more rapid visual recovery without affecting the long-term outcomes of vitrectomy for IMH. OCP is licensed for use in patients with small- or medium-sized holes and VMA. A greater success rate in using OCP has been reported in smaller holes, but further predictive factors for its success are needed to refine its use. It is important to counsel patients realistically regarding the rates of success with intravitreal OCP and its potential complications. Expansile gas can be considered as a further option in small holes with VMA; however, larger studies are required to provide guidance on its use.
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