ArticleThorax2016
Gastro-oesophageal reflux and worse asthma control in obese children: a case of symptom misattribution?
Article in Thorax, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Gastroesophageal Reflux Burden Before and After Exercise Challenge in Children with Poorly Controlled Asthma: A 48-Hour MII-pH Study.Advances in respiratory medicine · 2026Article
- Mechanistic study of inspiratory training in childhood Asthma: Rationale and methods of a pediatric clinical trial.Contemporary clinical trials communications · 2026Article
- Pediatric asthma comorbidities: Global impact and unmet needs.The World Allergy Organization journal · 2024Review
- Not Only Metabolic Complications of Childhood Obesity.Nutrients · 2024Review
- Management of the pediatric patient with asthma and obesity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- Childhood Obesity and Respiratory Diseases: Which Link?Children (Basel, Switzerland) · 2021Review
- Inflammation in Obesity-Related Complications in Children: The Protective Effect of Diet and Its Potential Role as a Therapeutic Agent.Biomolecules · 2020Review
- Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort.Pediatric research · 2020Article
- The Effects of Obesity in Asthma.Current allergy and asthma reports · 2019Review
- Genotype tailored treatment of mild symptomatic acid reflux in children with uncontrolled asthma (GenARA): Rationale and methods.Contemporary clinical trials · 2019Article
- Severe Asthma: Challenges and Pitfalls in Management.Indian journal of pediatrics · 2018Review
- Obesity and asthma.The Journal of allergy and clinical immunology · 2018Review
- Pediatric severe asthma: a case series report and perspectives on anti-IgE treatment.BMC pediatrics · 2018Review
- The effect of obesity, weight gain, and weight loss on asthma inception and control.Current opinion in allergy and clinical immunology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundObese children for unknown reasons report greater asthma symptoms. Asthma and obesity both independently associate with gastro-oesophageal reflux symptoms (GORS). Determining if obesity affects the link between GORS and asthma will help elucidate the obese-asthma phenotype.
objectiveExtend our previous work to determine the degree of associations between the GORS and asthma phenotype.
methodsWe conducted a cross-sectional study of lean (20%-65% body mass index, BMI) and obese (≥95% BMI) children aged 10-17 years old with persistent, early-onset asthma. Participants contributed demographics, GORS and asthma questionnaires and lung function data. We determined associations between weight status, GORS and asthma outcomes using multivariable linear and logistic regression. Findings were replicated in a second well-characterised cohort of asthmatic children.
resultsObese children had seven times higher odds of reporting multiple GORS (OR=7.7, 95% CI 1.9 to 31.0, interaction p value=.004). Asthma symptoms were closely associated with GORS scores in obese patients (r=0.815, p<0.0001) but not in leans (r=0.291, p=0.200; interaction p value=0.003). Higher GORS scores associated with higher FEV1-per cent predicted (p=0.003), lower airway resistance (R10, p=0.025), improved airway reactance (X10, p=0.005) but significantly worse asthma control (Asthma Control Questionnaire, p=0.007). A significant but weaker association between GORS and asthma symptoms was seen in leans compared with obese in the replicate cohort.
conclusionGORS are more likely to associate with asthma symptoms in obese children. Better lung function among children reporting gastro-oesophageal reflux and asthma symptoms suggests that misattribution of GORS to asthma may be a contributing mechanism to excess asthma symptoms in obese children.
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Registered trials
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