ArticleChemistry (Weinheim an der Bergstrasse, Germany)2016
Discovery, Characterization, and Analogue Synthesis of Bohemamine Dimers Generated by Non-enzymatic Biosynthesis.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Chalasoergodimers A-E, heterodimers with multiple polymerization modes from a marine-derived Chaetomium sp. fungus.Natural products and bioprospecting · 2025Article
- Dibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.Natural products and bioprospecting · 2025Article
- MarineMarine drugs · 2024Review
- Pyrrolizidine Alkaloids-Pros and Cons for Pharmaceutical and Medical Applications.International journal of molecular sciences · 2023Review
- Biomimetic Total Synthesis and Investigation of the Non-Enzymatic Chemistry of Oxazinin A.Angewandte Chemie (International ed. in English) · 2022Article
- Chimeric natural products derived from medermycin and the nature-inspired construction of their polycyclic skeletons.Nature communications · 2022Article
- Cytotoxic compounds from marine actinomycetes: Sources, Structures and Bioactivity.Acta materia medica · 2022Article
- Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid.Synthetic and systems biotechnology · 2021Article
- Synthesis of legonmycins A and B, C(7a)-hydroxylated bacterial pyrrolizidines.Beilstein journal of organic chemistry · 2021Article
- Synthesis and Investigation of the Abiotic Formation of Pyonitrins A-D.Organic letters · 2020Article
- Circumdatin-Aspyrone Conjugates from the Coral-AssociatedMarine drugs · 2019Article
- Elucidation of Spirodactylone, a Polycyclic Alkaloid from the Sponge Dactylia sp., and Nonenzymatic Generation from the Co-metabolite Denigrin B.Organic letters · 2019Article
- Mindapyrroles A-C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium.Journal of natural products · 2019Article
- Carpatizine, a novel bridged oxazine derivative generated by non-enzymatic reactions.Organic & biomolecular chemistry · 2017Article
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4 authors.
Funding
Abstract
Dibohemamines A-C (5-7), three new dimeric bohemamine analogues dimerized through a methylene group, were isolated from a marine-derived Streptomyces spinoverrucosus. The structures determined by spectroscopic analysis were confirmed through the semi-synthetic derivatization of monomeric bohemamines and formaldehyde. These reactions, which could occur under mild conditions, together with the detection of formaldehyde in the culture, revealed that this dimerization is a non-enzymatic process. In addition to the unique dimerization of the dibohemamines, dibohemamines B and C were found to have nm cytotoxicity against the non-small cell-lung cancer cell line A549. In view of the potent cytotoxicity of compounds 6 and 7, a small library of bohemamine analogues was generated for biological evaluation by utilizing a series of aryl and alkyl aldehydes.
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