Evidence map›Paper›PMID 26834027›Full record

ArticleSchizophrenia bulletin2016

Stress Sensitivity, Aberrant Salience, and Threat Anticipation in Early Psychosis: An Experience Sampling Study.

Ulrich Reininghaus, Matthew J Kempton, Lucia Valmaggia, Tom K J Craig, Philippa Garety, Adanna Onyejiaka, Charlotte Gayer-Anderson, Suzanne H So, Kathryn Hubbard, Stephanie Beards and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 11 pooled it
33.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 11 syntheses or guidelines pooled it, 305 citations in OpenAlex.

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  6. The ethnic density effect in psychosis: a systematic review and multilevel meta-analysis.The British journal of psychiatry : the journal of mental science · 2021
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 4 countries.

Ulrich ReininghausCentre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands; ulrich.reininghaus@kcl.ac.uk.
Matthew J KemptonPsychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Lucia ValmaggiaPsychology Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Tom K J CraigCentre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Philippa GaretyPsychology Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Adanna OnyejiakaPsychology Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Charlotte Gayer-AndersonCentre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Suzanne H SoDepartment of Psychology, The Chinese University of Hong Kong, Hong Kong, China;
Kathryn HubbardCentre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Stephanie BeardsCentre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Paola DazzanPsychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK;
Carmine ParianteNational Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Valeria MondelliNational Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Helen L FisherMRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
John G MillsPsychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK;
Wolfgang ViechtbauerDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands;
Philip McGuirePsychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK;
Jim van OsDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands;
Robin M MurrayPsychosis Studies Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK;
Til WykesPsychology Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK;
Inez Myin-GermeysDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands; Center for Contextual Psychiatry, Department of Neuroscience, Catholic University of Leuven, Leuven, Belgium.
Craig MorganCentre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK;
King's College London · GBMaastricht University · NLSouth London and Maudsley NHS Foundation Trust · GBChinese University of Hong Kong · CNNational Institute for Health Research · GB

Funding

Department of Health PDF-2011-04-065Department of Health RP-PG-0606-1049EPA EP-C-13-022Medical Research Council G0600972Medical Research Council G0700995Medical Research Council G108/603Medical Research Council G1100583Medical Research Council MR/J008915/1Medical Research Council MR/K004867/1Medical Research Council MR/K013807/1Wellcome Trust WT087417
6 · The paper itself

Abstract

While contemporary models of psychosis have proposed a number of putative psychological mechanisms, how these impact on individuals to increase intensity of psychotic experiences in real life, outside the research laboratory, remains unclear. We aimed to investigate whether elevated stress sensitivity, experiences of aberrant novelty and salience, and enhanced anticipation of threat contribute to the development of psychotic experiences in daily life. We used the experience sampling method (ESM) to assess stress, negative affect, aberrant salience, threat anticipation, and psychotic experiences in 51 individuals with first-episode psychosis (FEP), 46 individuals with an at-risk mental state (ARMS) for psychosis, and 53 controls with no personal or family history of psychosis. Linear mixed models were used to account for the multilevel structure of ESM data. In all 3 groups, elevated stress sensitivity, aberrant salience, and enhanced threat anticipation were associated with an increased intensity of psychotic experiences. However, elevated sensitivity to minor stressful events (χ(2)= 6.3,P= 0.044), activities (χ(2)= 6.7,P= 0.036), and areas (χ(2)= 9.4,P= 0.009) and enhanced threat anticipation (χ(2)= 9.3,P= 0.009) were associated with more intense psychotic experiences in FEP individuals than controls. Sensitivity to outsider status (χ(2)= 5.7,P= 0.058) and aberrantly salient experiences (χ(2)= 12.3,P= 0.002) were more strongly associated with psychotic experiences in ARMS individuals than controls. Our findings suggest that stress sensitivity, aberrant salience, and threat anticipation are important psychological processes in the development of psychotic experiences in daily life in the early stages of the disorder.

Indexed as

Ecological Momentary AssessmentAdolescentAdultAnticipation, PsychologicalFearFemaleHumansMaleMiddle AgedProdromal SymptomsPsychotic DisordersStress, PsychologicalYoung Adultaberrant salienceecological momentary assessmentfirst-episode psychosisprodromestress sensitivitythreat anticipation

Identifiers

PMID26834027
PMCPMC4838104
OpenAlexW2268291092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.