Evidence map›Paper›PMID 26834024›Full record

Trial reportSchizophrenia bulletin2016

Cost-Effectiveness of Comprehensive, Integrated Care for First Episode Psychosis in the NIMH RAISE Early Treatment Program.

Robert Rosenheck, Douglas Leslie, Kyaw Sint, Haiqun Lin, Delbert G Robinson, Nina R Schooler, Kim T Mueser, David L Penn, Jean Addington, Mary F Brunette and 8 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 56 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03919760 nacompletednot on this mapstarted 2020, after this paper: background citation

Enhancing Evidence-Based Practice for Youth and Emerging Adults With Early Psychosis: Implementation and Evaluation in Diverse Service Settings

TypeinterventionalSponsorCentre for Addiction and Mental HealthRan2020 to 2024Enrolled100ConditionsFirst Episode Psychosis, Schizophrenia, Childhood, Psychosis, SchizophreniaArmsNAVIGATE, Treatment as Usual
NCT07713849 recruitingnot on this mapstarted 2026, after this paper: background citation

Adapting and Improving Transition Care for First Episode Psychosis

Typeobservational_patient_registrySponsorUniversity of ChicagoRan2026 to 2029Enrolled75ConditionsSchizoaffective Disorders, Bipolar Disorder With Psychotic Features, Schizophrenia Disorders, Major Depressive Disorder With Psychotic FeaturesArmsTransition Care Team
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
  2. Economic Evaluation of Early Psychosis Interventions From A Canadian Perspective.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022
    Pooled it
  3. Economic analyses of supported employment programmes for people with mental health conditions: A systematic review.European psychiatry : the journal of the Association of European Psychiatrists · 2022
    Pooled it
  4. Pooled it
  5. Specialised early intervention teams for recent-onset psychosis.The Cochrane database of systematic reviews · 2020
    Pooled it
  6. Cost and effects of integrated care: a systematic literature review and meta-analysis.The European journal of health economics : HEPAC : health economics in prevention and care · 2020
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis.International journal of environmental research and public health · 2021
    Trial
  14. Trial
  15. Trial
  16. Pediatric Anxiety Disorders: A Cost of Illness Analysis.Journal of abnormal child psychology · 2020
    Trial
  17. Trial
  18. Trial
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Robert RosenheckDepartment of Psychiatry and Public Health, Yale Medical School, New Haven, CT; Robert.Rosenheck@Yale.Edu.
Douglas LeslieDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA;
Kyaw SintDepartment of Psychiatry and Public Health, Yale Medical School, New Haven, CT;
Haiqun LinDepartment of Psychiatry and Public Health, Yale Medical School, New Haven, CT;
Delbert G Robinson
Nina R SchoolerPsychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish, Glen Oaks, NY; Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY; Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY;
Kim T MueserCenter for Psychiatric Rehabilitation, Departments of Occupational Therapy, Psychiatry, and Psychology, Boston University, Boston, MA;
David L PennDepartment of Psychology, University of North Carolina-Chapel Hill, Chapel Hill, NC; School of Psychology, Australian Catholic University, Melbourne, Australia;
Jean AddingtonHotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Canada;
Mary F BrunetteGeisel School of Medicine at Dartmouth, Lebanon, NH; Bureau of Behavioral Health, DHHS, Concord, NH;
Christoph U Correll
Sue E EstroffDepartment of Social Medicine, University of North Carolina, Chapel Hill, NC;
Patricia MarcyPsychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish, Glen Oaks, NY;
James RobinsonNathan Kline Institute, Orangeburg, NY;
Joanne SevereNational Institute of Mental Health, Rockville, MD.
Agnes RuppNational Institute of Mental Health, Rockville, MD.
Michael SchoenbaumNational Institute of Mental Health, Rockville, MD.
John M Kane

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Longitudinal Mediation Analysis to Identify Effective Intervention Components in Clustered Trial of RAISE-ETP (Recovery after an Initial Schizophrenia Episode-Early Treatment Program)R03MH112053 · NIMH · YALE UNIVERSITY · PI LIN, HAIQUN · 2017 to 2018
$168k
ARRA NIH HHSNCATS NIH HHS UL1 TR001863NIMH NIH HHS HHSN271200900019CNIMH NIH HHS R03 MH112053
6 · The paper itself

Abstract

This study compares the cost-effectiveness of Navigate (NAV), a comprehensive, multidisciplinary, team-based treatment approach for first episode psychosis (FEP) and usual Community Care (CC) in a cluster randomization trial. Patients at 34 community treatment clinics were randomly assigned to either NAV (N = 223) or CC (N = 181) for 2 years. Effectiveness was measured as a one standard deviation change on the Quality of Life Scale (QLS-SD). Incremental cost effectiveness ratios were evaluated with bootstrap distributions. The Net Health Benefits Approach was used to evaluate the probability that the value of NAV benefits exceeded its costs relative to CC from the perspective of the health care system. The NAV group improved significantly more on the QLS and had higher outpatient mental health and antipsychotic medication costs. The incremental cost-effectiveness ratio was $12 081/QLS-SD, with a .94 probability that NAV was more cost-effective than CC at $40 000/QLS-SD. When converted to monetized Quality Adjusted Life Years, NAV benefits exceeded costs, especially at future generic drug prices.

Indexed as

Cost-Benefit AnalysisOutcome Assessment, Health CareAdolescentAdultCommunity Mental Health ServicesDelivery of Health Care, IntegratedFemaleHealth Services ResearchHumansMaleNational Institute of Mental Health (U.S.)Patient Care TeamPsychotic DisordersSchizophreniaUnited StatesYoung Adultcost-effectivenessquality adjusted life yearsschizophrenia

Identifiers

PMID26834024
PMCPMC4903057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.