ArticleAngewandte Chemie (International ed. in English)2016
Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Biosynthesis of 6-Hydroxymellein Requires a Collaborating Polyketide Synthase-like Enzyme.Angewandte Chemie (International ed. in English) · 2021Article
- Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore.Organic letters · 2020Article
- The role of the iterative modules in polyketide synthase evolution.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Fabclavine diversity inBeilstein journal of organic chemistry · 2020Article
- A Photoactivatable Small-Molecule Probe for the In Vivo Capture of Polyketide Intermediates.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- A Light-Activated Acyl Carrier Protein "Trap" for Intermediate Capture in Type II Iterative Polyketide Biocatalysis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Article
- Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes.Natural product reports · 2018Review
- Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly.Chemical communications (Cambridge, England) · 2016Review
- Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes.Angewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Chemical probes capable of reacting with KS (ketosynthase)-bound biosynthetic intermediates were utilized for the investigation of the model type I iterative polyketide synthase 6-methylsalicylic acid synthase (6-MSAS) in vivo and in vitro. From the fermentation of fungal and bacterial 6-MSAS hosts in the presence of chain termination probes, a full range of biosynthetic intermediates was isolated and characterized for the first time. Meanwhile, in vitro studies of recombinant 6-MSA synthases with both nonhydrolyzable and hydrolyzable substrate mimics have provided additional insights into substrate recognition, providing the basis for further exploration of the enzyme catalytic activities.
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Registered trials
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