Evidence map›Paper›PMID 26833814›Full record

ArticleThe European journal of neuroscience2016

Neurochemical and behavioural indices of exercise reward are independent of exercise controllability.

Jonathan J Herrera, Sofiya Fedynska, Parsa R Ghasem, Tyler Wieman, Peter J Clark, Nathan Gray, Esteban Loetz, Serge Campeau, Monika Fleshner, Benjamin N Greenwood

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European journal of neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jonathan J HerreraDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Sofiya FedynskaDepartment of Psychology, University of Colorado Denver, CB 173, PO Box 173364, Denver, 80217, CO, USA.
Parsa R GhasemDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Tyler WiemanDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Peter J ClarkDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Nathan GrayDepartment of Psychology, University of Colorado Denver, CB 173, PO Box 173364, Denver, 80217, CO, USA.
Esteban LoetzDepartment of Psychology, University of Colorado Denver, CB 173, PO Box 173364, Denver, 80217, CO, USA.
Serge CampeauDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Monika FleshnerDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Benjamin N GreenwoodDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
University of Colorado Boulder · USUniversity of Denver · USUniversity of Colorado Denver · US

Funding

The Neurobiology of the Stress Resistant BrainR01MH068283 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI FLESHNER, MONIKA · 2004 to 2014
$3.3M
Exercise Prevents Stress-Induced Memory ImpairmentsR03MH086665 · NIMH · UNIVERSITY OF COLORADO · PI GREENWOOD, BEN N · 2010 to 2011
$152k
NIMH NIH HHS R01 MH068283NIMH NIH HHS R03 MH086665
6 · The paper itself

Abstract

Brain reward circuits are implicated in stress-related psychiatric disorders. Exercise reduces the incidence of stress-related disorders, but the contribution of exercise reward to stress resistance is unknown. Exercise-induced stress resistance is independent of exercise controllability; both voluntary running (VR) and forced running (FR) protect rats against the anxiety-like and depression-like behavioural consequences of stress. Voluntary exercise is a natural reward, but whether rats find FR rewarding is unknown. Moreover, the contribution of dopamine (DA) and striatal reward circuits to exercise reward is not well characterized. Adult, male rats were assigned to locked wheels, VR, or FR groups. FR rats were forced to run in a pattern resembling the natural wheel running behavior of rats. Both VR and FR increased the reward-related plasticity marker ΔFosB in the dorsal striatum and nucleus accumbens, and increased the activity of DA neurons in the lateral ventral tegmental area, as revealed by immunohistochemistry for tyrosine hydroxylase and pCREB. Both VR and FR rats developed conditioned place preference (CPP) to the side of a CPP chamber paired with exercise. Re-exposure to the exercise-paired side of the CPP chamber elicited conditioned increases in cfos mRNA in direct-pathway (dynorphin-positive) neurons in the dorsal striatum and nucleus accumbens in both VR and FR rats, and in tyrosine hydroxylase-positive neurons in the lateral ventral tegmental area of VR rats only. The results suggest that the rewarding effects of exercise are independent of exercise controllability and provide insight into the DA and striatal circuitries involved in exercise reward and exercise-induced stress resistance.

Indexed as

Physical Conditioning, AnimalRewardAnimalsCorpus StriatumCyclic AMP Response Element-Binding ProteinDopaminergic NeuronsMaleNeuronal PlasticityNucleus AccumbensProto-Oncogene Proteins c-fosRatsRats, Inbred F344RunningStress, PsychologicalTyrosine 3-MonooxygenaseCyclic AMP Response Element-Binding ProteinProto-Oncogene Proteins c-fosTyrosine 3-Monooxygenasedopamineimmediate early genesratstriatumventral tegmental area

Identifiers

PMID26833814
PMCPMC4918765
OpenAlexW2265131300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.