Evidence map›Paper›PMID 26833775›Full record

ReviewMolecular nutrition & food research2016

Prevention and treatment of cancers by immune modulating nutrients.

Naveena B Janakiram, Altaf Mohammed, Venkateshwar Madka, Gaurav Kumar, Chinthalapally V Rao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular nutrition & food research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Reductive stress in cancer immunology and targeted therapy.Acta biochimica et biophysica Sinica · 2026
    Review
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  11. Article
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  17. The Role of Resveratrol in Cancer Therapy.International journal of molecular sciences · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Naveena B JanakiramCenter for Cancer Prevention and Drug Development, Hematology Oncology Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Altaf MohammedCenter for Cancer Prevention and Drug Development, Hematology Oncology Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Venkateshwar MadkaCenter for Cancer Prevention and Drug Development, Hematology Oncology Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Gaurav KumarCenter for Cancer Prevention and Drug Development, Hematology Oncology Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Chinthalapally V RaoCenter for Cancer Prevention and Drug Development, Hematology Oncology Section, Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
University of Oklahoma Health Sciences Center · US

Funding

HMG-CoA Reductase and Polyamine Inhibitors for Prevention of Colorectal CancerR01CA094962 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RAO, CHINTHALAPALLY V. · 2002 to 2014
$3.4M
Safer Approaches to CRC ChemopreventionR01CA213987 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RAO, CHINTHALAPALLY V. · 2017 to 2021
$2.4M
PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORSR01CA109247 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RAO, CHINTHALAPALLY V. · 2004 to 2008
$1.5M
Targeting mPGES-1/5-LOX for Prevention of CRC in High-Risk VeteransI01BX003198 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI RAO, CHINTHALAPALLY V. · 2016 to 2020
–
BLRD VA I01 BX003198NCI NIH HHS HHSN261201200013INCI NIH HHS N01 CN053300NCI NIH HHS R01 CA094962NCI NIH HHS R01 CA109247NCI NIH HHS R01 CA213987
6 · The paper itself

Abstract

Epidemiological and laboratory data support the protective effects of bioactive nutrients in our diets for various diseases. Along with various factors, such as genetic history, alcohol, smoking, exercise, and dietary choices play a vital role in affecting an individual's immune responses toward a transforming cell, by either preventing or accelerating a neoplastic transformation. Ample evidence suggests that dietary nutrients control the inflammatory and protumorigenic responses in immune cells. Immunoprevention is usually associated with the modulation of immune responses that help in resolving the inflammation, thus improving clinical outcome. Various metabolic pathway-related nutrients, including glutamine, arginine, vitamins, minerals, and long-chain fatty acids, are important components of immunonutrient mixes. Epidemiological studies related to these substances have reported different results, with no or minimal effects. However, several studies suggest that these nutrients may have immune-modulating effects that may lower cancer risk. Preclinical studies submit that most of these components may provide beneficial effects. The present review discusses the available data, the immune-modulating functions of these nutrients, and how these substances could be used to study immune modulation in a neoplastic environment. Further research will help to determine whether the mechanistic signaling pathways in immune cells altered by nutrients can be exploited for cancer prevention and treatment.

Indexed as

AnimalsArginineCatechinCell Line, TumorDietDisease Models, AnimalFatty Acids, UnsaturatedGlutamineHumansIsothiocyanatesLignansMeta-Analysis as TopicMicronutrientsNeoplasmsObservational Studies as TopicPhytochemicalsArginineCatechinepigallocatechin gallateFatty Acids, UnsaturatedGlutamineIsothiocyanatesLignansMicronutrientsPhytochemicalsPolyphenolsStilbenesBioactive agentsCancerImmune modulationMacronutrientsPhytochemicals

Identifiers

PMID26833775
PMCPMC6038926
OpenAlexW2324654953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.