ArticleGenes & development2016
Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans.
Article in Genes & development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the Caenorhabditis elegans germ line.Development (Cambridge, England) · 2026Article
- Cross-tissue coordination between SLC nucleoside transporters regulates reproduction in Caenorhabditis elegans.PLoS genetics · 2025Article
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- GSK3 coordinately regulates mitochondrial activity and nucleotide metabolism in quiescent oocytes.Biology open · 2025Article
- Nutritional vitamin B12 regulates RAS/MAPK-mediated cell fate decisions through one-carbon metabolism.Nature communications · 2024Article
- Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans.PLoS biology · 2024Article
- C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals.The Journal of clinical investigation · 2024Article
- Review
- Genetic and Chemical Controls of Sperm Fate and Spermatocyte Dedifferentiation via PUF-8 and MPK-1 inCells · 2023Article
- CTP synthase: the hissing of the cellular serpent.Histochemistry and cell biology · 2022Review
- Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Non-autonomous regulation of germline stem cell proliferation by somatic MPK-1/MAPK activity in C. elegans.Cell reports · 2021Article
- C. elegans: A biosensor for host-microbe interactions.Lab animal · 2021Review
- Recent Advances in the Genetic, Anatomical, and Environmental Regulation of theJournal of developmental biology · 2020Review
- mRNA Editing, Processing and Quality Control inGenetics · 2020Review
- Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion.Nature communications · 2020Article
- Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease.Cell reports · 2020Article
- Biology of theGenetics · 2019Review
- Article
- BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
Animals alter their reproductive programs to accommodate changes in nutrient availability, yet the connections between known nutrient-sensing systems and reproductive programs are underexplored, and whether there is a mechanism that senses nucleotide levels to coordinate germline proliferation is unknown. We established a model system in which nucleotide metabolism is perturbed in both the nematode Caenorhabditis elegans (cytidine deaminases) and its food (Escherichia coli); when fed food with a low uridine/thymidine (U/T) level, germline proliferation is arrested. We provide evidence that this impact of U/T level on the germline is critically mediated by GLP-1/Notch and MPK-1/MAPK, known to regulate germline mitotic proliferation. This germline defect is suppressed by hyperactivation of glp-1 or disruption of genes downstream from glp-1 to promote meiosis but not by activation of the IIS or TORC1 pathways. Moreover, GLP-1 expression is post-transcriptionally modulated by U/T levels. Our results reveal a previously unknown nucleotide-sensing mechanism for controlling reproductivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.