Evidence map›Paper›PMID 26833722›Full record

ReviewInternational wound journal2017

The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery.

Naghmeh Naderi, Emman J Combellack, Michelle Griffin, Tina Sedaghati, Muhammad Javed, Michael W Findlay, Christopher G Wallace, Afshin Mosahebi, Peter Em Butler, Alexander M Seifalian and 1 more

Abstract readReview
In one paragraph

Review in International wound journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  15. CELTCells · 2025
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Naghmeh NaderiReconstructive Surgery & Regenerative Medicine Group, Institute of Life Sciences (ILS), Swansea University Medical School, Swansea, UK.
Emman J CombellackReconstructive Surgery & Regenerative Medicine Group, Institute of Life Sciences (ILS), Swansea University Medical School, Swansea, UK.
Michelle GriffinUCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
Tina SedaghatiUCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
Muhammad JavedReconstructive Surgery & Regenerative Medicine Group, Institute of Life Sciences (ILS), Swansea University Medical School, Swansea, UK.
Michael W FindlayPlastic & Reconstructive Surgery, Stanford University Medical Centre, Stanford, CA, USA.
Christopher G WallacePlastic & Reconstructive Surgery, Royal Devon & Exeter Hospital, Exeter, UK.
Afshin MosahebiUCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
Peter Em ButlerDepartment of Plastic Surgery, Royal Free NHS Foundation Trust, London, UK.
Alexander M SeifalianUCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK.
Iain S WhitakerReconstructive Surgery & Regenerative Medicine Group, Institute of Life Sciences (ILS), Swansea University Medical School, Swansea, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs offers a paradigm shift in plastic and reconstructive surgery. The use of either embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) in clinical situations is limited because of regulations and ethical considerations even though these cells are theoretically highly beneficial. Adult mesenchymal stem cells appear to be an ideal stem cell population for practical regenerative medicine. Among these cells, adipose-derived stem cells (ADSC) have the potential to differentiate the mesenchymal, ectodermal and endodermal lineages and are easy to harvest. Additionally, adipose tissue yields a high number of ADSC per volume of tissue. Based on this background knowledge, the purpose of this review is to summarise and describe the proliferation and differentiation capacities of ADSC together with current preclinical data regarding the use of ADSC as regenerative tools in plastic and reconstructive surgery.

Indexed as

Adipose TissueAnimalsHumansPlastic Surgery ProceduresRegenerationStem CellsStem Cell TransplantationSurgery, PlasticADSCReconstructive surgeryStem cellsTissue engineering

Identifiers

PMID26833722
PMCPMC7949873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.