ArticleJournal of neurointerventional surgery2016
Quantitative assessment of device-clot interaction for stent retriever thrombectomy.
Article in Journal of neurointerventional surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review.Journal of neurointerventional surgery · 2017Pooled it
- Primary results from the CLEAR study of a novel stent retriever with drop zone technology.Journal of neurointerventional surgery · 2024Trial
- Making the invisible visible: integrated visualization and automated quantification of thrombus deformation during mechanical thrombectomy.Frontiers in medical technology · 2026Article
- Push and Fluff technique for optimization of clot integration with stent-retriever: An in vitro model.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Traditional Thrombus Composition and Related Endovascular Outcomes: Catching up with the Recent Evidence.Neurointervention · 2024Review
- Predictors of mTICI 2c/3 over 2b in patients successfully recanalized with mechanical thrombectomy.Annals of clinical and translational neurology · 2024Article
- In vitro models for the experimental evaluation of mechanical thrombectomy devices in acute ischemic stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Review
- A new aspiration device equipped with a hydro-separator for acute ischemic stroke due to challenging soft and stiff clots.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022Article
- Frictional force analysis of stent retriever devices using a realistic vascular model: Pilot study.Frontiers in neurology · 2022Article
- Efficacy of Balloon Guide Catheter-Assisted Thrombus Repair in Stroke Treatment: A Retrospective Survey in China.BioMed research international · 2022Article
- A Review of the Advancements in theFrontiers in medical technology · 2022Review
- SWI Susceptibility Vessel Sign in Patients Undergoing Mechanical Thrombectomy for Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2021Article
- Preclinical testing platforms for mechanical thrombectomy in stroke: a review on phantoms, in-vivo animal, and cadaveric models.Journal of neurointerventional surgery · 2021Review
- Article
- Characterization of thrombus composition with multimodality CT-based imaging: an in-vitro study.Journal of neurointerventional surgery · 2021Article
- Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing.AJNR. American journal of neuroradiology · 2021Article
- Applicability assessment of a stent-retriever thrombectomy finite-element model.Interface focus · 2021Article
- Biomechanics and hemodynamics of stent-retrievers.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Review
- Clot Analog Attenuation in Non-contrast CT Predicts Histology: an Experimental Study Using Machine Learning.Translational stroke research · 2020Article
- A neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy.Nature communications · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRapid revascularization in emergent large vessel occlusion with endovascular embolectomy has proven clinical benefit. We sought to measure device-clot interaction as a potential mechanism for efficient embolectomy.
methodsTwo different radiopaque clot models were injected to create a middle cerebral artery occlusion in a patient-specific vascular phantom. A radiopaque stent retriever was deployed within the clot by unsheathing the device or a combination of unsheathing followed by pushing the device (n=8/group). High-resolution cone beam CT was performed immediately after device deployment and repeated after 5 min. An image processing pipeline was created to quantitatively evaluate the volume of clot that integrates with the stent, termed the clot integration factor (CIF).
resultsThe CIF was significantly different for the two deployment variations when the device engaged the hard clot (p=0.041), but not the soft clot (p=0.764). In the hard clot, CIF increased significantly between post-deployment and final imaging datasets when using the pushing technique (p=0.019), but not when using the unsheathing technique (p=0.067). When we investigated the effect of time on CIF in the different clot models disregarding the technique, the CIF was significantly increased in the final dataset relative to the post-deployment dataset in both clot models (p=0.004-0.007).
conclusionsThis study demonstrates in an in vitro system the benefit of pushing the Trevo stent during device delivery in hard clot to enhance integration. Regardless of delivery technique, clot-device integration increased in both clot models by waiting 5 min.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.