ArticleClinical medicine (London, England)2016
Non-melanoma skin cancer.
Article in Clinical medicine (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 10 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Unraveling the controversy: exploring the link between sex hormones and skin cancers through a meta-analysis and systematic review.Archives of dermatological research · 2025Pooled it
- Exogenous hormone therapy and non-melanoma skin cancer (keratinocyte carcinoma) risk in women: a systematic review and meta-analysis.BMC cancer · 2023Pooled it
- Roles of Cannabinoids in Melanoma: Evidence from In Vivo Studies.International journal of molecular sciences · 2020Pooled it
- Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Computer-assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Optical coherence tomography for diagnosing skin cancer in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Reflectance confocal microscopy for diagnosing keratinocyte skin cancers in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Exfoliative cytology for diagnosing basal cell carcinoma and other skin cancers in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Teledermatology for diagnosing skin cancer in adults.The Cochrane database of systematic reviews · 2018Pooled it
- High-frequency ultrasound for diagnosing skin cancer in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Effectiveness and Patient Experiences of Rhenium Skin Cancer Therapy for Nonmelanoma Skin Cancer: Interim Results from the EPIC-Skin Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Trial
- Ethosome-based drug delivery system for precision targeting and tumour microenvironment reprogramming in non-invasive skin cancer therapy.Discover nano · 2026Review
- Modern brachytherapy modalities vs. external beam radiotherapy in post-operative non-melanoma skin cancer: A systematic review.Journal of contemporary brachytherapy · 2026Review
- Machine learning-guided bioelectrical impedance mapping for rapid adjunctive margin assessment in Mohs surgery.npj biomedical innovations · 2026Article
- Nonresponse of basal cell carcinomas to immune checkpoint inhibition therapy for melanoma: A case series.JAAD case reports · 2026Article
- Demographic and regional trends in Nonmelanoma skin cancer mortality in the United States, 1999-2020.BMC cancer · 2026Observational
- Global regional and national burden of nonmelanoma skin cancer from 1990 to 2021 based on the global burden of disease 2021 study.Discover oncology · 2026Article
- Real-world analysis of multiple myeloma treatments in England using the Cancer Analysis System registry.Scientific reports · 2026Article
- Skin Cancer Among Patients at a Major University Hospital in Saudi Arabia: A Retrospective, Single-Center Study.Clinical, cosmetic and investigational dermatology · 2026Article
- Skin Cancer in Residential Care Facilities: A Scoping Review of Risk, Diagnosis, Psychosocial Impact, and Management.Cureus · 2026Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-melanoma skin cancer (NMSC) comprises basal cell carcinoma (BCC) and squamous cell carcinoma, together with a host of rare tumours. NMSC is the commonest malignancy among Caucasians and its incidence continues to rise annually. Exposure to UV radiation initiates approximately 90% of NMSC, causing malignant transformation of keratinocytes and suppression of the inflammatory response. Risk factors include sun exposure and immunosuppression. There are several subtypes of BCC, although histological overlap is common. Surgery has traditionally been regarded as the 'gold-standard' treatment, offering excellent cure rates and cosmetic results. Other treatment modalities include physical destruction (radiotherapy, curettage and cautery, and cryotherapy), chemical destruction (photodynamic therapy and topical 5-flurouracil) and immunomodulatory therapy (topical imiquimod). The recent development of novel hedgehog pathway inhibitors for high-risk BCC (including oral vismodegib and sonidegib) may represent a paradigm shift towards medical management of NMSC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.