Evidence map›Paper›PMID 26833487›Full record

ReviewIrish journal of medical science2016

Get the GIST? An overview of gastrointestinal stromal tumours.

G A Watson, D Kelly, M Melland-Smith, J Gleeson, G McEntee, C M Kelly, J A McCaffrey

Abstract readReview
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In one paragraph

Review in Irish journal of medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Low Distribution of TIM-3Journal of immunology research · 2021
    Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

G A WatsonDepartment of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland. geoff_watson7@hotmail.com.
D KellyDepartment of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
M Melland-SmithDepartment of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
J GleesonDepartment of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
G McEnteeDepartment of Surgery, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
C M KellyDepartment of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
J A McCaffreyDepartment of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GISTs are the most common mesenchymal neoplasms of the gastrointestinal tract. The last 20 years have been revolutionary in the understanding of these tumours and began with the discovery of c-KIT, a proto oncogene that when mutated forms the molecular basis for the growth and development of these malignancies. Surgery was previously considered to be the only treatment modality in both local and advanced disease, however, the introduction of immunotherapy agents such as tyrosine kinase inhibitors has had profound effects on how we now approach and manage these tumours. These novel agents have significantly reduced the frequency of disease recurrence and dramatically improved survival, and serve as a model for the study of targeted therapies in other solid tumors. We present a review of gastrointestinal stromal tumours and consider the current evidence based detection and management of these unique tumors.

Indexed as

Antineoplastic AgentsGastrointestinal NeoplasmsGastrointestinal Stromal TumorsHumansNeoplasm Recurrence, LocalProto-Oncogene MasProto-Oncogene Proteins c-kitAntineoplastic AgentsMAS1 protein, humanProto-Oncogene MasProto-Oncogene Proteins c-kitc-KITGastrointestinal stromal tumors (GIST)Imatinib mesylateReview

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.