ArticleMuscle & nerve2016
Analysis of fluid movement in skeletal muscle using fluorescent microspheres.
Article in Muscle & nerve, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- The important role of cellular mechanical microenvironment in engineering structured cultivated meat: Recent advances.Current research in food science · 2024Review
- Modelling intramuscular drug fateInternational journal of pharmaceutics: X · 2022Article
- Reduced growth rate of aged muscle stem cells is associated with impaired mechanosensitivity.Aging · 2022Article
- Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche.Biophysical journal · 2021Article
- On the characterization of interstitial fluid flow in the skeletal muscle endomysium.Journal of the mechanical behavior of biomedical materials · 2020Article
- ---Mechanosensitivity of aged muscle stem cells.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Evaluate muscle tension using intramuscular pressure device in rabbit tibialis anterior model for improved tendon transfer surgery.Physiological measurement · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionRegional variability in interstitial fluid pressure confounds use of intramuscular pressure measurement to assess muscle force. It is hypothesized that interstitial flow is dependent on intramuscular pressure. The goal of this study was to assess the feasibility of using fluorescent microspheres to evaluate movement of interstitial fluid in skeletal muscle.
methodsTwo diameters of fluorescent microspheres were injected into the rat tibialis anterior during both static (n = 6) and passively lengthened (10% strain) experimental conditions (n = 6). Microsphere dispersion was evaluated using confocal imaging of transverse muscle sections.
resultsFluorescent microspheres tracked interstitial fluid while not penetrating the muscle fiber. When compared with the static condition, significantly greater dispersion (P = 0.003) was seen with passively lengthened conditions (17 ± 9% vs. 31 ± 7%, respectively). Dispersion did not differ for the 2 microsphere sizes (P = 0.811).
conclusionsFluorescent microspheres track movement of interstitial fluid, and dispersion is dependent on passive lengthening. Muscle Nerve 54: 444-450, 2016.
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Registered trials
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