ArticleAlcoholism, clinical and experimental research2016
Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers.
Article in Alcoholism, clinical and experimental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Polygenic liability for schizophrenia predicts shifting-specific executive function deficits and tobacco use in a moderate drinking community sample.Psychiatry research · 2019Pooled it
- Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and polysubstance-dependent individuals.The European journal of neuroscience · 2019Trial
- Social Mistreatment Effect on Alcohol Misuse Trajectories Is Moderated by Subcortical Network Activation During Error Processing.Addiction biology · 2026Article
- Dysregulation of inhibitory control in young adult binge drinkers: Neuroimaging evidence of gender differences associated with misusing alcohol to cope with negative affect.Addiction neuroscience · 2025Article
- Comprehensive Analysis of Event-Related Potentials of Response Inhibition: The Role of Negative Urgency and Compulsivity.Psychophysiology · 2025Article
- Inhibitory control in the sober state as a function of alcohol sensitivity: a pilot functional magnetic resonance imaging (fMRI) study.Frontiers in human neuroscience · 2025Article
- Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking.Brain sciences · 2024Article
- Threat bias and resting state functional connectivity of the amygdala and bed nucleus stria terminalis.Journal of psychiatric research · 2020Article
- Article
- Neural oscillatory dynamics of inhibitory control in young adult binge drinkers.Biological psychology · 2019Article
- Structural and functional cerebral bases of diminished inhibitory control during healthy aging.Human brain mapping · 2018Article
- Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers.Brain connectivity · 2018Article
- Behavioral and Brain Activity Indices of Cognitive Control Deficits in Binge Drinkers.Brain sciences · 2018Article
- An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry.Molecular psychiatry · 2017Article
- Inhibitory control and response monitoring are not systematically related to weekly alcohol consumption in the general population.Psychopharmacology · 2017Article
- Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study.NeuroImage. Clinical · 2017Article
- Functional Domains of Substance Use and their Implications to Trauma: A Systematic Review of Neuroimaging Studies.Chronic stress (Thousand Oaks, Calif.)Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDeficits in inhibitory control have been widely implicated in alcohol misuse. However, the literature does not readily distinguish the effects of drinking problems and chronic alcohol use. Here, we examined how years of drinking and the Alcohol Use Disorders Identification Test (AUDIT) score each influences the cerebral responses to inhibitory control in nondependent drinkers.
methodsFifty-seven adult drinkers and 57 age- and gender-matched nondrinkers participated in one 40-minute functional magnetic resonance imaging scan of the stop signal task. Data were preprocessed and modeled using SPM8. In a regression model, we contrasted stop and go success trials for individuals and examined activities of response inhibition each in link with the AUDIT score and years of alcohol use in group analyses. We specified the effects of duration of use by contrasting regional activations of drinkers and age-related changes in nondrinkers. In mediation analyses, we investigated how regional activities mediate the relationship between drinking problems and response inhibition.
resultsHigher AUDIT score but not years of drinking was positively correlated with prolonged stop signal reaction time (SSRT) and diminished responses in the cerebellum, thalamus, frontal and parietal regions, independent of years of alcohol use. Further, activity of the thalamus, anterior cingulate cortex, and presupplementary motor area significantly mediates the association, bidirectionally, between the AUDIT score and SSRT. The duration of alcohol use was associated with decreased activation in the right inferior frontal gyrus extending to superior temporal gyrus, which was not observed for age-related changes in nondrinkers.
conclusionsThe results distinguished the association of drinking problems and years of alcohol use to inhibitory control in young adult nondependent drinkers. These new findings extend the imaging literature of alcohol misuse and may have implications for treatment to prevent the escalation from social to dependent drinking. More research is needed to confirm age-independent neural correlates of years of alcohol use.
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