Evidence map›Paper›PMID 26833246›Full record

SynthesisNature communications2016

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Yingchang Lu, Felix R Day, Stefan Gustafsson, Martin L Buchkovich, Jianbo Na, Veronique Bataille, Diana L Cousminer, Zari Dastani, Alexander W Drong, Tõnu Esko and 249 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  14. The Osteoporotic Fractures in Men study (MrOS): a 25-yr landmark study of skeletal health in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
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  17. Review
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  20. The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review

129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

259 authors.

Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Felix R DayMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-3789-7651
Stefan GustafssonScience for Life Laboratory, Uppsala University, 750 85 Uppsala, Sweden.ORCID http://orcid.org/0000-0001-5894-0351
Martin L BuchkovichDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Jianbo NaDepartment of Developmental and Regenerative Biology, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Veronique BatailleWest Herts NHS Trust, Herts HP2 4AD, UK.
Diana L CousminerInstitute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
Zari DastaniDepartment Epidemiology, Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
Alexander W DrongWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Tõnu EskoEstonian Genome Center, Univeristy of Tartu, Tartu, 51010, Estonia.
David M EvansUniversity of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia.
Mario FalchiDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.
Teresa FerreiraWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Åsa K HedmanScience for Life Laboratory, Uppsala University, 750 85 Uppsala, Sweden.
Robin HaringInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Pirro G HysiDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Mark M IlesLeeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds, Leeds LS9 7TF, UK.
Anne E JusticeDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Vasiliki LagouWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Rui LiDepartment Epidemiology, Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
Xin LiDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Adam LockeCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Chen LuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Reedik MägiWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
John R B PerryMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Tune H PersDivisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Qibin QiDepartment of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Marianna SannaDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Ellen M SchmidtDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
William R ScottDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Dmitry ShunginLund University Diabetes Centre, Department of Clinical Science, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial, 205 02 Malmö, Sweden.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Anna A E VinkhuyzenQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Ryan W WalkerThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Harm-Jan WestraProgram in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Mingfeng ZhangDepartment of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Zhihong ZhuQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Uzma AfzalDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Tarunveer Singh AhluwaliaNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Stephan J L BakkerUniversity of Groningen, University Medical Center Groningen, Department of Medicine, 9700 RB Groningen, The Netherlands.
Claire BellisDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78245, USA.
Amélie BonnefondCNRS UMR 8199, F-59019 Lille, France.
Katja BorodulinNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
Tommy CederholmDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, 751 85 Uppsala, Sweden.
Audrey C ChohLifespan Health Research Center, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45420, USA.
Hyung Jin ChoiDepartment of Anatomy, Seoul National University College of Medicine, Seoul 03080, Korea.
Joanne E CurranSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas 78520.
Lisette C P G M de GrootDepartment of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.
Philip L De JagerProgram in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Rosalie A M Dhonukshe-RuttenDepartment of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.
Anke W EnnemanDepartment of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Elodie EuryCNRS UMR 8199, F-59019 Lille, France.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, California 94107, USA.
Tom ForsenDepartment of General Practice and Primary Health Care, University of Helsinki, FI-00014 Helsinki, Finland.
Nele FriedrichInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Frédéric FumeronINSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
Melissa E GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland 20892, USA.
Simone GärtnerDepartment of Medicine A, University Medicine Greifswald, 17475 Greifswald, Germany.
Bok-Ghee HanCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 370914, Korea.
Aki S HavulinnaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Dena HernandezLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
Hans HillegeUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.
Till IttermannInstitute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Jack W KentDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78245, USA.
Ivana KolcicDepartment of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia.
Tiina LaatikainenNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Jari LahtiFolkhälsan Research Centre, FI-00290 Helsinki, Finland.
Irene Mateo LeachUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.
Christine G LeeDepartment of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.
Jong-Young LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 370914, Korea.
Tian LiuMax Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, 14195 Berlin, Germany.
Youfang LiuThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina 27599-7280, USA.
Stéphane LobbensCNRS UMR 8199, F-59019 Lille, France.
Marie LohDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
Carolina Medina-GomezDepartment of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Karl MichaëlssonDepartment of Surgical Sciences, Orthopedics, Uppsala University, 751 85 Uppsala, Sweden.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
Carrie M NielsonSchool of Public Health, Oregon Health &Science University, Portland, Oregon 97239, USA.
Laticia OozageerEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Laura PascoeInstitute of Cell &Molecular Biosciences, Newcastle University, Newcastle NE1 7RU, UK.
Lavinia PaternosterMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited.
Ozren PolašekDepartment of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia.
Samuli RipattiInstitute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
Mark A SarzynskiHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA.
Chan Soo ShinDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
Nina Smolej NarančićInstitute for Anthropological Research, Zagreb 10000, Croatia.
Dominik SpiraThe Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.
Priya SrikanthSchool of Public Health, Oregon Health &Science University, Portland, Oregon 97239, USA.
Elisabeth Steinhagen-ThiessenThe Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.
Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Karin M A SwartEMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.
Leena TaittonenDepartment of Pediatrics, University of Oulu, FI-90014 Oulu, Finland.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
Emmi TikkanenInstitute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
Nathalie van der VeldeDepartment of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Natasja M van SchoorEMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.
Niek VerweijUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.
Alan F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
Joseph M ZmudaDepartment of Epidemiology; University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Niina EklundNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Terrence ForresterTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Anne U JacksonCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Kati KristianssonInstitute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
Teemu KuulasmaaFaculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Johanna KuusistoFaculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Peter LichtnerInstitute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Satu MännistöNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Cameron D PalmerBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.
Janina S RiedInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Alena StancákováDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Peter J WagnerInstitute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
Ayse DemirkanGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
Angela DöringInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur 201, Iceland.
Douglas P KielDepartment of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115.
Brigitte KühnelInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Barbara McknightCardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Jeffrey R O'ConnellProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Ben A OostraGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
Alan R ShuldinerProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Kijoung SongGenetics, Projects Clinical Platforms and Sciences, GlaxoSmithKline, Philadelphia, Pennsylvania 19112, USA.
Liesbeth VandenputCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
Cornelia M van DuijnNetherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.
Peter VollenweiderDepartment of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
Charles C WhiteDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Michael BoehnkeCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Yvonne BoettcherUniversity of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
Richard S CooperDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 61053, USA.
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Harald GrallertInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Aroon HingoraniInstitute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
Torben JørgensenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Pekka JousilahtiNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Mika KivimakiDepartment of Epidemiology and Public Health, UCL, London WC1E 6BT, UK.
Meena KumariDepartment of Epidemiology and Public Health, UCL, London WC1E 6BT, UK.
Markku LaaksoFaculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Allan LinnebergResearch Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark.
Amy LukeDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 61053, USA.
Colin A MckenzieTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica.
Aarno PalotieInstitute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Bamidele O TayoDepartment of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 61053, USA.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
Lars BertramSchool of Public Health, Faculty of Medicine, Imperial College London, London W6 8RP, UK.
John BlangeroSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas 78520.
Matthias BlüherUniversity of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA.
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Nam H ChoAjou University School of Medicine, Department of Preventive Medicine, Suwon Kyoung-gi 443-721, Korea.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, California 94107, USA.
Stefan A CzerwinskiLifespan Health Research Center, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45420, USA.
Ilja DemuthThe Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.
Rahel EckardtThe Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.
Johan G ErikssonNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
Oscar H FrancoNetherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.
Philippe FroguelCNRS UMR 8199, F-59019 Lille, France.
Ron T GansevoortUniversity of Groningen, University Medical Center Groningen, Department of Medicine, 9700 RB Groningen, The Netherlands.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland 20892, USA.
Nicholas HastieMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Markku HeliövaaraNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Albert HofmanNetherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.
Joanne M JordanThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina 27599-7280, USA.
Antti JulaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland.
Eero KajantieNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Paul B KnektNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Seppo KoskinenNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Peter KovacsUniversity of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
Terho LehtimäkiDepartment of Clinical Chemistry, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
Lars LindDepartment of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden.
Yongmei LiuCenter for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Eric S OrwollBone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA.
Clive OsmondMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
Markus PerolaInstitute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
Louis PérusseDepartment of Kinesiology, Laval University, Québec City, Quebec, Canada G1V 0A6.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA.
D C RaoDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Veikko SalomaaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Thorkild I A SørensenMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited.
Michael StumvollUniversity of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
Anke TönjesUniversity of Leipzig, Department of Medicine, 04103 Leipzig, Germany.
Bradford TowneLifespan Health Research Center, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45420, USA.
Gregory J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, California 94107, USA.
Angelo TremblayDepartment of Kinesiology, Laval University, Québec City, Quebec, Canada G1V 0A6.
André G UitterlindenDepartment of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Pim van der HarstUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.
Erkki VartiainenNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Jorma S ViikariDepartment of Medicine, University of Turku, FI-20521 Turku, Finland.
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Marie-Claude VohlInstitute of Nutrition and Functional Foods, Laval University, Québec City, Quebec, Canada G1V 0A6.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Mark WalkerProgram in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Henri WallaschofskiInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Sarah WildCentre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
James F WilsonMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Loïc YengoCNRS UMR 8199, F-59019 Lille, France.
D Timothy BishopLeeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds, Leeds LS9 7TF, UK.
Ingrid B BoreckiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
Abbas DehghanDepartment of Epidemiology, Erasmus Medical Center, 3000CA Rotterdam/Zuidholland, The Netherlands.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Ghazaleh FatemifarMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited.
Caroline FoxHarvard Medical School, Boston, Massachusetts 02115, USA.
Terrence S FureyDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Lude FrankeUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.
Jiali HanDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA.
David J HunterBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.
Juha KarjalainenDepartment of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
Robert C KaplanDepartment of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Jaspal S KoonerEaling Hospital NHS Trust, Middlesex UB1 3HW, UK.
Mark I McCarthyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Joanne M MurabitoBoston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, Massachusetts 02118, USA.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Julia A N BishopLeeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds, Leeds LS9 7TF, UK.
Kari E NorthCarolina Center for Genome Sciences and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA.
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
Ken K OngMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Inga ProkopenkoWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.ORCID http://orcid.org/0000-0003-1624-7457
J Brent RichardsDepartment Epidemiology, Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
Eric E SchadtIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Elisabeth WidénInstitute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
Cristen J WillerDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.ORCID http://orcid.org/0000-0001-5645-4966
Jian YangQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.ORCID http://orcid.org/0000-0003-2001-2474
Erik IngelssonScience for Life Laboratory, Uppsala University, 750 85 Uppsala, Sweden.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Joel N HirschhornBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.
John Andrew PospisilikDepartment of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, D-76108 Freiburg, Germany.ORCID http://orcid.org/0000-0002-9745-0977
M Carola ZillikensDepartment of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
Cecilia LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Tuomas Oskari KilpeläinenMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 1991 to 2020
$49.1M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1M
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7M
Genetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2M
Integrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3M
Genetic Architecture of Adiposity in Multiple Large CohortsR01DK089256 · NIDDK · WASHINGTON UNIVERSITY · PI BARANSKI, THOMAS JOHN, LIU, CHING-TI · 2010 to 2016
$4.6M
The Aging Genome Association Study "AGE-GAIN"ZIAAG000965 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$4.0M
Arthritis Research UKBiotechnology and Biological Sciences Research CouncilBritish Heart FoundationCancer Research UK 10589Cancer Research UK 19167Chief Scientist OfficeCIHRCSRD VA IK2 CX000729Department of HealthEuropean Research Council 281641Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_U106179472Medical Research Council MC_U147574242Medical Research Council MC_UP_A100_1003Medical Research Council MC_UP_A620_1016Medical Research Council MC_UU_12011/3Medical Research Council MC_UU_12011/4Medical Research Council MC_UU_12013/4Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/5Medical Research Council MR/J010642/1Medical Research Council MR/J012165/1Medical Research Council MR/K002414/1Medical Research Council MR/K006584/1Medical Research Council MR/K013351/1NHLBI NIH HHS K01 HL129892NHLBI NIH HHS R01 HL117078NIAMS NIH HHS K01 AR062655NIAMS NIH HHS R01 AR041398NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG027574NIA NIH HHS U24 AG051129NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R01 DK106236NIDDK NIH HHS U01 DK062370Wellcome Trust
6 · The paper itself

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Indexed as

Genetic Predisposition to DiseaseAdiposityAnimalsDrosophila melanogasterGene Expression RegulationGene Knockdown TechniquesGenome-Wide Association StudyHeart DiseasesHumansQuantitative Trait Loci

Identifiers

PMID26833246
PMCPMC4740398

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