ArticleAntimicrobial agents and chemotherapy2016
Combination of Amphotericin B and Flucytosine against Neurotropic Species of Melanized Fungi Causing Primary Cerebral Phaeohyphomycosis.
Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Fluorescence of Cladophialophora Bantiana After Administration of 5-Aminolevulinic Acid Hydrochloride: Case Report.Neurosurgery practice · 2025Article
- Spectrum of clinically significant melanized fungi in NIH hospitalized patients and their antifungal susceptibility profiles.Medical mycology · 2025Article
- Antifungal Susceptibility of Melanized Fungi Isolated from CARD9 Deficient Patients: Implications for Treatment of Refractory Infections.Mycopathologia · 2025Article
- Severe Sporotrichosis Caused by Sporothrix brasiliensis: Antifungal Susceptibility and Clinical OutcomesJournal of fungi (Basel, Switzerland) · 2022Article
- The convoluted process of diagnosing pulmonary mycosis caused by Exophiala dermatitidis: a case report.BMC infectious diseases · 2022Article
- Intracranial fungalSurgical neurology international · 2022Article
- Exophiala dermatitidis.World journal of clinical cases · 2021Article
- Cerebral phaeohyphomycosis due toCurrent medical mycology · 2020Article
- 1,3-Thiazine, 1,2,3,4-Dithiadiazole, and Thiohydrazide Derivatives Affect Lipid Bilayer Properties and Ion-Permeable Pores Induced by Antifungals.Frontiers in cell and developmental biology · 2020Article
- Review
- Cerebral Phaeohyphomycosis Caused byFrontiers in neurology · 2019Article
- Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis.Antimicrobial agents and chemotherapy · 2018Article
- Review
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Authors and funding
12 authors at 8 institutions in 6 countries.
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Abstract
Primary central nervous system phaeohyphomycosis is a fatal fungal infection due mainly to the neurotropic melanized fungiCladophialophora bantiana,Rhinocladiella mackenziei, andExophiala dermatitidis.Despite the combination of surgery with antifungal treatment, the prognosis continues to be poor, with mortality rates ranging from 50 to 70%. Therefore, a search for a more-appropriate therapeutic approach is urgently needed. Ourin vitrostudies showed that with the combination of amphotericin B and flucytosine against these species, the median fractional inhibitory concentration (FIC) indices for strains ranged from 0.25 to 0.38, indicating synergy. By use of Bliss independence analysis, a significant degree of synergy was confirmed for all strains, with the sum ΔE ranging from 90.2 to 698.61%. No antagonism was observed. These results indicate that amphotericin B, in combination with flucytosine, may have a role in the treatment of primary cerebral infections caused by melanized fungi belonging to the orderChaetothyriales Furtherin vivostudies and clinical investigations to elucidate and confirm these observations are warranted.
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