ArticleNeuron2016
Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed.
- The Parafascicular Role in Updating Action from a Spatial to a Visual Strategy Is Driven by Its Glutamatergic Mesencephalic Locomotor Region Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Behavior- and Cell Type-Specific Cortico-Striatal Decoupling in a Parkinson's Disease-Like Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Complementary cortical and thalamic contributions to cell type-specific striatal activity dynamics during movement.Science advances · 2026Article
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- Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior.eLife · 2025Article
- Acute transcutaneous auricular vagus nerve stimulation modulates presynaptic SV2A density in healthy rat brain: An in vivo microPET study.Psychophysiology · 2025Article
- Individualized cortico-basal ganglia network effective connectivity predicts outcomes of STN-DBS in patients with Parkinson's disease.Frontiers in neuroscience · 2025Article
- Corticostriatal glutamate-mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model.Clinical and translational medicine · 2024Article
- Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input.Cell reports · 2024Article
- Dysfunction of motor cortices in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- Dopamine depletion weakens direct pathway modulation of SNr neurons.Neurobiology of disease · 2024Article
- Dopamine-mediated plasticity preserves excitatory connections to direct pathway striatal projection neurons and motor function in a mouse model of Parkinson's disease.bioRxiv : the preprint server for biology · 2024Article
- Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024Review
- Updating the striatal-pallidal wiring diagram.Nature neuroscience · 2024Review
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- Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement.eLife · 2023Article
- Ongoing movement controls sensory integration in the dorsolateral striatum.Nature communications · 2023Article
- Connectivity of the corticostriatal and thalamostriatal systems in normal and parkinsonian states: An update.Neurobiology of disease · 2022Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
Movement suppression in Parkinson's disease (PD) is thought to arise from increased efficacy of the indirect pathway basal ganglia circuit, relative to the direct pathway. However, the underlying pathophysiological mechanisms remain elusive. To examine whether changes in the strength of synaptic inputs to these circuits contribute to this imbalance, we obtained paired whole-cell recordings from striatal direct- and indirect-pathway medium spiny neurons (dMSNs and iMSNs) and optically stimulated inputs from sensorimotor cortex or intralaminar thalamus in brain slices from control and dopamine-depleted mice. We found that dopamine depletion selectively decreased synaptic strength at thalamic inputs to dMSNs, suggesting that thalamus drives asymmetric activation of basal ganglia circuitry underlying parkinsonian motor impairments. Consistent with this hypothesis, in vivo chemogenetic and optogenetic inhibition of thalamostriatal terminals reversed motor deficits in dopamine-depleted mice. These results implicate thalamostriatal projections in the pathophysiology of PD and support interventions targeting thalamus as a potential therapeutic strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.