Evidence map›Paper›PMID 26833098›Full record

ArticleNature communications2016

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Tuomas O Kilpeläinen, Jayne F Martin Carli, Alicja A Skowronski, Qi Sun, Jennifer Kriebel, Mary F Feitosa, Åsa K Hedman, Alexander W Drong, James E Hayes, Jinghua Zhao and 167 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

177 authors.

Tuomas O KilpeläinenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.
Jayne F Martin CarliDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Alicja A SkowronskiInstitute of Human Nutrition, Columbia University, New York, New York 10032, USA.
Qi SunChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA.
Jennifer KriebelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.
Mary F FeitosaDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Åsa K HedmanScience for Life Laboratory, Uppsala University, Uppsala 750 85, Sweden.
Alexander W DrongWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
James E HayesCell and Developmental Biology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA.
Jinghua ZhaoMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Tune H PersThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.
Ursula SchickGenetics of Obesity and Related Metabolic Traits Program, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Niels GrarupThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.
Zoltán KutalikInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne 1010, Switzerland.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden 2333, The Netherlands.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Kati KristianssonDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Marian BeekmanDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere FI-33101, Finland.
Joel ErikssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
Peter HennemanDepartment of Human Genetics, Leiden University Medical Center, Leiden 2333, The Netherlands.
Jari LahtiInstitute of Behavioural Sciences, University of Helsinki, Helsinki FI-00014, Finland.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
Jian'an LuanMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Fabiola Del Greco MCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC) - Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy.
Dorota PaskoGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö 20502, Sweden.
Sara M WillemsDepartment of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachussetts 02215, USA.
Xiuqing GuoDepartment of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, California 90502, USA.
Yongmei LiuCenter for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Marcus E KleberMedical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Mannheim 68167, Germany.
Louis PérusseDepartment of Kinesiology, Laval University, Quebec City, Quebec, Canada G1V 0A6.
Tom GauntMRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK.
Tarunveer S AhluwaliaThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.
Yun Ju SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Yolande F RamosDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.
Antoinette AmuzuFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Inês BarrosoWellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Claire BellisHuman Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore 138672, Singapore.
John BlangeroTexas Biomedical Research Institute, San Antonio, Texas 78245, USA.
Brendan M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Cork T12 YT57, Ireland.
Stefan BöhringerDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Yii-Der I ChenDepartment of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, California 90502, USA.
Anton J N de CraenDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333, The Netherlands.
David R CrosslinDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
Caroline E DaleFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Zari DastaniDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada H3A 0G4.
Felix R DayMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Joris DeelenDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Graciela E DelgadoMedical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Mannheim 68167, Germany.
Ayse DemirkanGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.
Francis M FinucaneMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK.
Melissa E GarciaNational Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 2089, USA.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.
Stefan GustafssonScience for Life Laboratory, Uppsala University, Uppsala 750 85, Sweden.
Göran HallmansDepartment of Biobank Research, Umeå University, Umeå 90187, Sweden.
Susan E HankinsonChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA.
Aki S HavulinnaDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Christian HerderGerman Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany.
Dena HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA.
Andrew A HicksCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC) - Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy.
David J HunterDepartment of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Thomas IlligResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.
Erik IngelssonScience for Life Laboratory, Uppsala University, Uppsala 750 85, Sweden.
Andreea Ioan-FacsinayDepartment of Rheumatology, Leiden University Medical Center, Leiden 2333, The Netherlands.
John-Olov JanssonDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg 41345, Sweden.
Nancy S JennyLaboratory for Clinical Biochemistry Research, Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Colchester, Vermont 05405, USA.
Marit E JørgensenSteno Diabetes Center, Gentofte DK-2820, Denmark.
Torben JørgensenResearch Centre for Prevention and Health, Glostrup University Hospital, Glostrup 2600, Denmark.
Magnus KarlssonClinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedic Surgery, Lund University, Skåne University Hospital, Malmö 21428, Sweden.
Wolfgang KoenigDepartment of Internal Medicine II - Cardiology, University of Ulm, Ulm 89081, Germany.
Peter KraftDepartment of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachussetts 02115, USA.
Joanneke KwekkeboomDepartment of Rheumatology, Leiden University Medical Center, Leiden 2333, The Netherlands.
Tiina LaatikainenDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Karl-Heinz LadwigInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
Charles A LeDucDivision of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York 10029, USA.
Gordon LoweInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Yingchang LuGenetics of Obesity and Related Metabolic Traits Program, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Pedro Marques-VidalDepartment of Internal Medicine, Lausanne University Hospital, Lausanne 1011, Switzerland.
Christa MeisingerInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Richard H MyersDepartment of Neurology, Boston University School of Medicine, Boston, Massachussetts 02118, USA.
Satu MännistöDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA.
Lavinia PaternosterMRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
Aruna D PradhanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachussetts 02215, USA.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA.
Laura J Rasmussen-TorvikPreventive Medicine, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Wolfgang RathmannInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
J Brent RichardsDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachussetts 02215, USA.
Naveed SattarFaculty of Medicine, BHF Glasgow Cardiovascular Research Centre, Glasgow G12 8QQ, UK.
David B SavageThe University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Stefan SöderbergDepartment of Public Health and Clinical Medicine, Cardiology and Heart Centre, Umeå University, Umeå 90187, Sweden.
Nicholas J TimpsonMRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK.
Liesbeth VandenputCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
Diana van HeemstDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333, The Netherlands.
Hae-Won UhDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Marie-Claude VohlInstitute of Nutrition and Functional Foods, Quebec City, Quebec, Canada G1V 0A6.
Mark WalkerInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Heinz-Erich WichmannInstitute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität and Klinikum Grosshadern, Munich 80336, Germany.
Elisabeth WidénInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki FI-00290, Finland.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Jie YaoDepartment of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, California 90502, USA.
Tanja ZellerGerman Center for Cardiovascular Research (DZHK e.V.), partner site Hamburg/Kiel/Lübeck, Hamburg 20246, Germany.
Yiying ZhangDivision of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York 10029, USA.
Ingrid MeulenbeltDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Margreet KloppenburgDepartment of Rheumatology, Leiden University Medical Center, Leiden 2333, The Netherlands.
Arne AstrupFaculty of Science, Department of Nutrition, Exercise, and Sports, University of Copenhagen, Copenhagen 1165, Denmark.
Thorkild I A SørensenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.
Mark A SarzynskiHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA.
D C RaoDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Pekka JousilahtiDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Erkki VartiainenDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Albert HofmanDepartment of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.
André G UitterlindenDepartment of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.
Eero KajantieDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Clive OsmondMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
Aarno PalotieInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki FI-00290, Finland.
Johan G ErikssonDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Markku HeliövaaraDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Paul B KnektDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Seppo KoskinenDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Antti JulaDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Markus PerolaDepartment of Health, National Institute for Health and Welfare, Helsinki FI-00271, Finland.
Risto K HuupponenDepartment of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku FI-20520, Finland.
Jorma S ViikariDivision of Medicine, Turku University Hospital, Turku FI-20520, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere FI-33521, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere FI-33101, Finland.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku FI-2051, Finland.
Dan MellströmCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
Mattias LorentzonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
Juan P CasasFarr Institute of Health Informatics, University College London, London NW1 2DA, UK.
Stefanie BandinelliGeriatric Unit, Azienda Sanitaria Firenze, Florence 50122, Italy.
Winfried MärzMedical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Mannheim 68167, Germany.
Aaron IsaacsGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.
Ko W van DijkDepartment of Human Genetics, Leiden University Medical Center, Leiden 2333, The Netherlands.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, The Netherlands.
Tamara B HarrisLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, Maryland 20892, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA.
Matthew A AllisonFamily and Preventive Medicine, University of California-San Diego, La Jolla, California 92161, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachussetts 02215, USA.
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Peter P PramstallerCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC) - Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy.
Ingrid B BoreckiDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Dawn M WaterworthGlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA.
Sven BergmannSwiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
Gérard WaeberDepartment of Internal Medicine, Lausanne University Hospital, Lausanne 1011, Switzerland.
Peter VollenweiderDepartment of Internal Medicine, Lausanne University Hospital, Lausanne 1011, Switzerland.
Henrik VestergaardThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DIKU Building, Copenhagen 2100, Denmark.
Frank B HuDepartment of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
P Eline SlagboomDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
J W JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden 2333, The Netherlands.
Robert J KleinIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Erik E SchadtIcahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Paul W FranksDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachussetts 02115, USA.
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Rudolph L LeibelDivision of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York 10029, USA.
Ruth J F LoosMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SPIEGELMAN, DONNA L · 1991 to 2009
$41.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
British Heart Foundation PG/07/131/24254British Heart Foundation PG/13/66/30442CIHR FRCN-CCT-83028Intramural NIH HHSMedical Research Council G0701863Medical Research Council G9815508Medical Research Council MC_U106179471Medical Research Council MC_U106179472Medical Research Council MC_U147574242Medical Research Council MC_UP_A620_1016Medical Research Council MC_UU_12011/3Medical Research Council MC_UU_12011/4Medical Research Council MC_UU_12013/3Medical Research Council MC_UU_12013/8Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MR/J012165/1NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1-TR-000040NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1-TR-001079NCI NIH HHS CA047988NCI NIH HHS CA055075NCI NIH HHS CA087969NCI NIH HHS CA49449NCI NIH HHS CA50385NCI NIH HHS CA65725NCI NIH HHS CA67262NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA065725NCI NIH HHS R01 CA067262NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA067262NCI NIH HHS U01 CA098233NCI NIH HHS U01CA098233NCI NIH HHS UM1 CA182913NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1-RR-24156NCRR NIH HHS UL1-RR-25005NHGRI NIH HHS HG004399NHGRI NIH HHS HG004446NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004399NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG007033NHGRI NIH HHS U01-HG007033NHLBI NIH HHS 5R01HL068891NHLBI NIH HHS 5R01HL087700NHLBI NIH HHS HL-043851NHLBI NIH HHS HL-045670NHLBI NIH HHS HL080467NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-65226NHLBI NIH HHS N01-HC95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R00 HL098459NHLBI NIH HHS R00-HL-098459NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL068891NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01-HL-071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01-HL-071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01-HL-071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01-HL-071251NHLBI NIH HHS R01 HL071252NHLBI NIH HHS R01-HL-071252NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01-HL-071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01-HL-071259NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL087700NHLBI NIH HHS R01 HL088451NHLBI NIH HHS R01-HL-088451NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01HL117078NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01AG62103NIA NIH HHS R01 AG032098NIDDK NIH HHS 1R01DK080015NIDDK NIH HHS 5R01DK068336NIDDK NIH HHS 5R01DK075681NIDDK NIH HHS 5R01DK07568102NIDDK NIH HHS DK058845NIDDK NIH HHS DK-26687NIDDK NIH HHS DK52431NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK026687NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK052431NIDDK NIH HHS R01 DK058845NIDDK NIH HHS R01 DK068336NIDDK NIH HHS R01 DK075681NIDDK NIH HHS R01 DK080015NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01DK089256NIMHD NIH HHS 263 MD 821336NIMHD NIH HHS 263MD9164NIMHD NIH HHS R01 MD009164PHS HHS HHSN26800625226CWellcome Trust 081917/Z/07/ZWellcome Trust 086596/Z/08/ZWellcome Trust 090532Wellcome Trust 202802/Z/16/ZWellcome Trust WT064890Wellcome Trust WT089062Wellcome Trust WT090532Wellcome Trust WT091551Wellcome Trust WT098017Wellcome Trust WT098051
6 · The paper itself

Abstract

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health.

Indexed as

Genome-Wide Association StudyAdipose TissueAnimalsGene Expression RegulationGene Knockdown TechniquesLeptinMaleMiceRNA, MessengerTissue Culture TechniquesLeptinRNA, Messenger

Identifiers

PMID26833098
PMCPMC4740377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.