ArticleScientific reports2016
The Effect of Oxytocin on Third-Party Altruistic Decisions in Unfair Situations: An fMRI Study.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Oxytocin in Antisocial Personality Disorders: A Systematic Review of the Literature.Frontiers in psychiatry · 2019Pooled it
- Oxytocinergic modulation of speech production-a double-blind placebo-controlled fMRI study.Social cognitive and affective neuroscience · 2023Trial
- Neurobiological Mechanisms of Responding to Injustice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Trial
- Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans.Brain connectivity · 2017Trial
- The Causal Role of Temporoparietal Junction in Mediating Self-Other Mergence during Mentalizing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Can monetary incentives overturn fairness-based decisions?Royal Society open science · 2023Article
- The OXTR rs53576 impacts moral permissibility of attempted but failed harms in populations of students and prisoners.Social cognitive and affective neuroscience · 2022Article
- Neural correlates of product attachment to cosmetics.Scientific reports · 2021Article
- Oxytocin Facilitates Self-Serving Rather Than Altruistic Tendencies in Competitive Social Interactions Via Orbitofrontal Cortex.The international journal of neuropsychopharmacology · 2019Article
- Neurocognitive mechanisms of reactions to second- and third-party justice violations.Scientific reports · 2019Article
- Interactive effects of OXTR and GAD1 on envy-associated behaviors and neural responses.PloS one · 2019Article
- An Eye for an Eye: Neural Correlates of the Preference for Punishment-Based Justice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The good lies: Altruistic goals modulate processing of deception in the anterior insula.Human brain mapping · 2017Article
- Other-regarding attention focus modulates third-party altruistic choice: An fMRI study.Scientific reports · 2017Article
- The (Null) Effect of Affective Touch on Betrayal Aversion, Altruism, and Risk Taking.Frontiers in behavioral neuroscience · 2017Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans display an intriguing propensity to help the victim of social norm violations or punish the violators which require theory-of-mind (ToM)/mentalizing abilities. The hypothalamic peptide oxytocin (OXT) has been implicated in modulating various pro-social behaviors/perception including trust, cooperation, and empathy. However, it is still elusive whether OXT also influences neural responses during third-party altruistic decisions, especially in ToM-related brain regions such as the temporo-parietal junction (TPJ). To address this question, we conducted a pharmacological functional magnetic resonance imaging experiment with healthy male participants in a randomized, double-blind, cross-over design. After the intranasal administration synthetic OXT (OXT(IN)) or placebo (PLC), participants could transfer money from their own endowment to either punish a norm violator or help the victim. In some trials, participants observed the decisions made by a computer. Behaviorally, participants under OXT(IN) showed a trend to accelerate altruistic decisions. At the neural level, we observed a strong three-way interaction between drug treatment (OXT/PLC), agency (self/computer), and decision (help/punish), such that OXT(IN) selectively enhanced activity in the left TPJ during observations of others being helped by the computer. Collectively, our findings indicate that OXT enhances prosocial-relevant perception by increasing ToM-related neural activations.
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