ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2016
Food intake inhibition in rainbow trout induced by activation of serotonin 5-HT2C receptors is associated with increases in POMC, CART and CRF mRNA abundance in hypothalamus.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Inhibitory neurotransmitter serotonin and excitatory neurotransmitter dopamine both decrease food intake in Chinese perch (Siniperca chuatsi).Fish physiology and biochemistry · 2018Trial
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- Synthetic Feed Attractants in European Seabass (Animals : an open access journal from MDPI · 2025Article
- G proteins of the GScience advances · 2025Article
- Effects of different acute stressors on the regulation of appetite genes in the carp (Royal Society open science · 2023Article
- Unraveling the periprandial changes in brain serotonergic activity and its correlation with food intake-related neuropeptides in rainbow troutFrontiers in endocrinology · 2023Article
- New Insights Into the Evolution of Corticotropin-Releasing Hormone Family With a Special Focus on Teleosts.Frontiers in endocrinology · 2022Article
- Viral Infection Drives the Regulation of Feeding Behavior Related Genes inInternational journal of molecular sciences · 2021Article
- Risperidone stimulates food intake and induces body weight gain via the hypothalamic arcuate nucleus 5-HT2c receptor-NPY pathway.CNS neuroscience & therapeutics · 2020Article
- Dietary Tryptophan Induces Opposite Health-Related Responses in the Senegalese Sole (Frontiers in physiology · 2019Article
- Stress Effects on the Mechanisms Regulating Appetite in Teleost Fish.Frontiers in endocrinology · 2018Review
- Identification and functional characterisation of 5-HT4 receptor in sea cucumber Apostichopus japonicus (Selenka).Scientific reports · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
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Abstract
In rainbow trout, the food intake inhibition induced by serotonin occurs through 5-HT2C and 5-HT1A receptors, though the mechanisms involved are still unknown. Therefore, we assessed if a direct stimulation of 5-HT2C and 5-HT1A serotonin receptors (resulting in decreased food intake in rainbow trout), affects gene expression of neuropeptides involved in the control of food intake, such as pro-opiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART), corticotrophin releasing factor (CRF), and agouti-related peptide (AgRP). In a first set of experiments, the injection of the 5-HT2C receptor agonists MK212 (60 μg kg(-1) icv) and WAY 161503 (1 mg kg(-1) ip), and of the 5-HT1A receptor agonist 8-OH-DPAT (1 mg kg(-1) ip and 30 μg kg(-1) icv) induced food intake inhibition. In a second set of experiments, we observed that the injection of MK212 or WAY 161503 (1 and 3 mg kg(-1)) significantly increased hypothalamic POMC mRNA abundance. CART mRNA abundance in hypothalamus was enhanced by treatment with MK212 and unaffected by WAY 161503. The administration of the 5-HT1A receptor agonist 8-OH-DPAT did not induce any significant variation in the hypothalamic POMC or CART mRNA levels. CRF mRNA abundance was only affected by MK212 that increased hypothalamic values. Finally, hypothalamic AgRP mRNA abundance was only evaluated with the agonist 5-HT2C MK212 resulting in no significant effects. The results show that the reduction in food intake mediated by 5-HT2C receptors is associated with increases in hypothalamic POMC, CART and CRF mRNA abundance.
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