Evidence map›Paper›PMID 26832888›Full record

Trial reportThe journal of spinal cord medicine2016

Effects of progesterone and vitamin D on outcome of patients with acute traumatic spinal cord injury; a randomized, double-blind, placebo controlled study.

Bahram Aminmansour, Ali Asnaashari, Majid Rezvani, Fariborz Ghaffarpasand, Seyed Mohammad Amin Noorian, Masih Saboori, Parisa Abdollahzadeh

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of spinal cord medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 0 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Article
  8. Critical Care of Spinal Cord Injury.Current neurology and neuroscience reports · 2024
    Review
  9. Article
  10. Article
  11. Observational
  12. The Role of Vitamins in Spinal Cord Injury: Mechanisms and Benefits.Oxidative medicine and cellular longevity · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Nutrition in the Neurocritical Care Unit: a New Frontier.Current treatment options in neurology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Bahram Aminmansoura Department of Neurosurgery , Isfahan University of Medical Sciences , Isfahan , Iran.
Ali Asnaasharia Department of Neurosurgery , Isfahan University of Medical Sciences , Isfahan , Iran.
Majid Rezvania Department of Neurosurgery , Isfahan University of Medical Sciences , Isfahan , Iran.
Fariborz Ghaffarpasandb Neurosciences Research Center , Shiraz University of Medical Sciences , Shiraz , Iran.
Seyed Mohammad Amin Noorianc Student Research Committee , Isfahan University of Medical Sciences , Isfahan , Iran.
Masih Sabooria Department of Neurosurgery , Isfahan University of Medical Sciences , Isfahan , Iran.
Parisa Abdollahzadehd Department of Psychiatry , University of Social Welfare and Rehabilitation Sciences , Tehran , Iran.
Isfahan University of Medical Sciences · IRUniversity of Social Welfare and Rehabilitation Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSteroid hormones offer promising therapeutic perspectives during the acute phase of spinal cord injury (SCI) while the role of progesterone and vitamin D remain controversial. The aim of the current study was to investigate the effects of progesterone and vitamin D on functional outcome of patients with acute traumatic SCI.

methodsThis was a randomized clinical trial including 64 adult patients with acute traumatic SCI admitted within 8 hours of injury. All the patients received methylprednisolone on admission according to standard protocol (30 mg/kg as bolus dose and 15 mg/kg each 3 hours up to 24 hours). Patients were randomly assigned to receive intramuscular injection of 0.5 mg/kg progesterone twice daily and 5µg/kg oral vitamin D3 twice daily up to 5 days (n = 32) or placebo (n = 32). Patients were visited 6 days, 3 and 6 months after injury and motor and sensory function was assessed according to American Spinal Injury Association (ASIA) score.

resultsThere was no significant difference between two study groups regarding age (P = 0.341), sex (P = 0.802) and therapy lag (P = 0.609). The motor powers and sensory function increased significantly after 6 months in both study groups. Those who received progesterone and vitamin D had significantly higher motor powers and sensory function after 6 months of therapy. Those who received the therapy within 4 hours of injury, had significantly higher motor powers and sensory function 6 months after treatment in progesterone and vitamin D group. Therapy lag was negatively associated with 6-month motor powers and sensory function in progesterone and vitamin D group.

conclusionsAdministration of progesterone and vitamin D in acute phase of traumatic SCI is associated with better functional recovery and outcome.

Indexed as

AdolescentAdultFemaleHumansInjections, IntramuscularMaleMethylprednisoloneMiddle AgedMotor ActivityProgesteroneSensationSpinal Cord InjuriesVitamin DMethylprednisoloneProgesteroneVitamin DFunctional recoveryOutcomesProgesteroneSpinal cord injuryVitamin D

Identifiers

PMID26832888
PMCPMC5073761
OpenAlexW966664313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.