ArticleNature communications2016
Affinity and competition for TBP are molecular determinants of gene expression noise.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Article
- High-resolution binding data of TFIID and cofactors show promoter-specific differences in vivo.Research square · 2026Article
- High-resolution binding data of TFIID and cofactors show promoter-specific differencesbioRxiv : the preprint server for biology · 2025Article
- Deciphering the Contribution of TATA Box and 5'UTR to Defense Signaling in Rice Under Blast Infection.Biology · 2025Review
- Mot1 regulation of promoter binding by TBP varies with stress and gene expression levels independently of coactivator dependence.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistance.FEMS microbiology reviews · 2025Review
- Optimal solution to the set cover problem with a vicinity constraint for estimating genotype tissue expression profiles.Bioinformatics advances · 2025Article
- Genome-scale chromatin binding dynamics of RNA Polymerase II general transcription machinery components.The EMBO journal · 2024Article
- Candidate SNP Markers Significantly Altering the Affinity of TATA-Binding Protein for the Promoters of Human Hub Genes for Atherogenesis, Atherosclerosis and Atheroprotection.International journal of molecular sciences · 2023Article
- Transcription factor binding process is the primary driver of noise in gene expression.PLoS genetics · 2022Article
- Article
- Comparative studies of genomic and epigenetic factors influencing transcriptional variation in two insect species.G3 (Bethesda, Md.) · 2022Article
- Predicting which genes will respond to transcription factor perturbations.G3 (Bethesda, Md.) · 2022Article
- DNA-induced spatial entrapment of general transcription machinery can stabilize gene expression in a nondividing cell.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Two promoters integrate multiple enhancer inputs to drive wild-type knirps expression in the Drosophila melanogaster embryo.Genetics · 2021Article
- The switch of DNA states filtering the extrinsic noise in the system of frequency modulation.Scientific reports · 2021Article
- Gene expression variability in human and chimpanzee populations share common determinants.eLife · 2020Article
- A SARS-CoV-2 host infection model network based on genomic human Transcription Factors (TFs) depletion.Heliyon · 2020Article
- Gene Transcription as a Limiting Factor in Protein Production and Cell Growth.G3 (Bethesda, Md.) · 2020Article
- Predictive features of gene expression variation reveal mechanistic link with differential expression.Molecular systems biology · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cell-to-cell variation in gene expression levels (noise) generates phenotypic diversity and is an important phenomenon in evolution, development and disease. TATA-box binding protein (TBP) is an essential factor that is required at virtually every eukaryotic promoter to initiate transcription. While the presence of a TATA-box motif in the promoter has been strongly linked with noise, the molecular mechanism driving this relationship is less well understood. Through an integrated analysis of multiple large-scale data sets, computer simulation and experimental validation in yeast, we provide molecular insights into how noise arises as an emergent property of variable binding affinity of TBP for different promoter sequences, competition between interaction partners to bind the same surface on TBP (to either promote or disrupt transcription initiation) and variable residence times of TBP complexes at a promoter. These determinants may be fine-tuned under different conditions and during evolution to modulate eukaryotic gene expression noise.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.