Trial reportBMC complementary and alternative medicine2016
Safety and acceptability of Lactobacillus reuteri DSM 17938 and Bifidobacterium longum subspecies infantis 35624 in Bangladeshi infants: a phase I randomized clinical trial.
Trial report in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of Probiotics in Bangladeshi Infants
Safety, Tolerability and Effect on Fecal Microbiota Composition of Two Probiotic Strains in Infants
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Effect of Probiotic Lactobacillus Strains on Porphyromonas gingivalis, the Etiological Factor of Periodontal Diseases-A Systematic Review.Probiotics and antimicrobial proteins · 2026Pooled it
- Probiotics in Term Infants: Clinical Impact of Infant-Type Bifidobacteria: A Systematic Review and Meta-analyses.The Journal of nutrition · 2025Pooled it
- Probiotics to prevent infantile colic.The Cochrane database of systematic reviews · 2019Pooled it
- Effect of Nitazoxanide and Probiotic Treatment on Bangladeshi Children with Cryptosporidiosis.The American journal of tropical medicine and hygiene · 2025Trial
- Safety and tolerability of Bifidobacterium longum subspecies infantis EVC001 supplementation in healthy term breastfed infants: a phase I clinical trial.BMC pediatrics · 2017Trial
- Effectiveness ofInternational journal of clinical pediatric dentistry · 2026Article
- Probiotic Dairy Innovations: Exploring Buffalo Milk Potential for Food Product Development.Comprehensive reviews in food science and food safety · 2025Review
- Nourishing the Infant Gut Microbiome to Support Immune Health: Protocol of SUN (Seeding Through Feeding) Randomized Controlled Trial.JMIR research protocols · 2024Article
- Effects ofNutrients · 2024Article
- Effects of neonatal nutrition interventions on neonatal mortality and child health and development outcomes: A systematic review.Campbell systematic reviews · 2021Review
- Immunomodulation of dendritic cells by Lactobacillus reuteri surface components and metabolites.Physiological reports · 2021Article
- Metagenomic sequencing of stool samples in Bangladeshi infants: virome association with poliovirus shedding after oral poliovirus vaccination.Scientific reports · 2020Article
- Slums, Space, and State of Health-A Link between Settlement Morphology and Health Data.International journal of environmental research and public health · 2020Article
- Evolutionary changes of an intestinal Lactobacillus reuteri during probiotic manufacture.MicrobiologyOpen · 2020Article
- Exploiting Prophage-Mediated Lysis for Biotherapeutic Release byApplied and environmental microbiology · 2019Article
- Evidence of inflated exclusive breastfeeding estimates from a clinical trial in Bangladesh.International breastfeeding journal · 2018Article
- Role ofFrontiers in microbiology · 2018Review
- Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis.Bone research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundProbiotics have rarely been studied in young healthy infants from low-income countries. This phase I study investigated the safety and acceptability of two probiotics in Bangladesh.
methodsHealthy infants aged four to twelve weeks from urban slums in Bangladesh were randomized to one of three different intervention dosing arms (daily, weekly, biweekly - once every two weeks) of Lactobacillus reuteri DSM 17938 and Bifidobacterium longum subspecies infantis 35624 over one month or to a fourth arm that received no probiotics. All subjects were followed for two additional months. Reported gastrointestinal and respiratory symptoms as well as breastfeeding rates, hospitalizations, differential withdrawals, and caretakers' perception of probiotic use were compared among arms.
resultsIn total, 160 infants were randomized (40 to each arm) with 137 (Daily n = 35, Weekly n = 35, Biweekly n = 35, Control n = 32) followed up for a median of twelve weeks; 113 completed the study. Illness and breastfeeding rates were similar across all arms. Ten hospitalizations unrelated to probiotic use occurred. Forty eight percent of the caretakers of infants in intervention arms believed that probiotics improved their baby's health.
conclusionsThese two commonly used probiotics appeared safe and well-accepted by Bangladeshi families.
trial registrationClinicalTrials.gov NCT01899378 . Registered July 10, 2013.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.