Evidence map›Paper›PMID 26832340›Full record

SynthesisEndocrine2016

Association of depression with pre-diabetes, undiagnosed diabetes, and previously diagnosed diabetes: a meta-analysis.

Shengguang Chen, Qian Zhang, Guoxing Dai, Jiawen Hu, Chenting Zhu, Lijie Su, Xianzheng Wu

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Endocrine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 5 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 5 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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  16. Journal of diabetes and metabolic disorders · 2025
    Review
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shengguang ChenDepartment of Emergency, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
Qian ZhangDepartment of Nuclear Medicine, Shanghai Tenth People's Hospital, Shanghai, China.
Guoxing DaiDepartment of Emergency, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
Jiawen HuDepartment of Emergency, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
Chenting ZhuDepartment of Emergency, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
Lijie SuDepartment of Emergency, Tongji Hospital Affiliated to Tongji University, Shanghai, China.
Xianzheng WuDepartment of Emergency, Tongji Hospital Affiliated to Tongji University, Shanghai, China. xianzh_wu@163.com.
Tongji Hospital · CNTongji University · CNShanghai Tenth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed a meta-analysis to analyze the associations of depression with pre-diabetes (PreDM), undiagnosed diabetes (UDM), and previously diagnosed diabetes (PDM), and whether the association was affected by important study characteristics. We searched relevant articles published in PubMed and EMBASE up to August, 2015. Studies reporting cross-sectional associations of depression with PreDM, UDM, or PDM compared with normal glucose metabolism (NGM) were included. Odds ratios (ORs) were pooled with random-effect and fixed-effect models. Subgroup analyses by sex, study mean age, different degrees of adjustment, publication year, quality score, and depression assessment scales were also performed. Twenty studies were eligible and included in current analysis. Summary estimates showed that compared with NGM individuals, prevalence of depression was moderately increased in PreDM (random-effect odds ratio (OR) 1.11, 95 % confidence interval (CI) 1.03-1.19) and UDM (OR 1.27, 95 % CI 1.02-1.59), and markedly increased in PDM (OR 1.80, 95 % CI 1.40-2.31). Subgroup analyses showed that the positive association remained only among studies with mean age <60 years old but not among those with mean age ≥60 years old. Summary estimates of ORs with cardiovascular disease adjustment substantially attenuated the association. Our findings suggested that risk of prevalent depression was gradually increased with the deterioration of glucose metabolism among younger age groups but not among older age groups. Comorbid cardiovascular diseases might be an important intermediate factor underlying the association between depression and diabetes.

Indexed as

ComorbidityDepressionDepressive DisorderDiabetes MellitusHumansPrediabetic StatePrevalenceDepressionMeta-analysisPre-diabetesUndiagnosed diabetes

Identifiers

PMID26832340
OpenAlexW2259576172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.