Evidence map›Paper›PMID 26832339›Full record

Trial reportPsychopharmacology2016

The effect of a dopamine antagonist on conditioning of sexual arousal in women.

Mirte Brom, Ellen Laan, Walter Everaerd, Philip Spinhoven, Baptist Trimbos, Stephanie Both

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mirte BromInstitute of Psychology, Clinical Psychology Unit, Leiden University, Wassenaarseweg 52, Leiden, 2333, AK, The Netherlands. m.brom@lumc.nl.
Ellen LaanDepartment of Sexology and Psychosomatic Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.
Walter EveraerdDepartment Clinical Psychology, University of Amsterdam, Weesperplein 4, 1018, XA, Amsterdam, The Netherlands.
Philip SpinhovenInstitute of Psychology, Clinical Psychology Unit, Leiden University, Wassenaarseweg 52, Leiden, 2333, AK, The Netherlands.
Baptist TrimbosDepartment of Gynaecology, Leiden University Medical Centre, P.O. Box 9600, 2300, RC, Leiden, The Netherlands.
Stephanie BothDepartment of Psychosomatic Gynaecology & Sexology, VRSP, Leiden University Medical Centre, Rijnsburgerweg 10, Zone PG4-Z, P.O. Box 9600, 2300, RC, Leiden, The Netherlands.
Leiden University · NLUniversity of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleDopamine (DA) plays a key role in reward-seeking behaviours. Accumulating evidence from animal and human studies suggests that human sexual reward learning may also depend on DA transmission. However, research on the role of DA in human sexual reward learning is completely lacking.

objectivesTo investigate whether DA antagonism attenuates classical conditioning of sexual response in humans.

methodsHealthy women were randomly allocated to one of two treatment conditions: haloperidol (n = 29) or placebo (n = 29). A differential conditioning paradigm was applied with genital vibrostimulation as unconditional stimulus (US) and neutral pictures as conditional stimuli (CSs). Genital arousal was assessed, and ratings of affective value and subjective sexual arousal were obtained.

resultsHaloperidol administration affected unconditional genital responding. However, no significant effects of medication were found for conditioned responding.

conclusionsNo firm conclusions can be drawn about whether female sexual reward learning implicates DA transmission since the results do not lend themselves to unambiguous interpretation.

Indexed as

AdolescentAdultConditioning, ClassicalDopamine AntagonistsEmotionsFemaleHaloperidolHumansLibidoMiddle AgedRewardSexual BehaviorYoung AdultDopamine AntagonistsHaloperidolDopamine antagonistHaloperidolSexual conditioningSexual responseSexual reward learning

Identifiers

PMID26832339
PMCPMC4801988
OpenAlexW2273348098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.