ArticleObesity surgery2016
A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery.
Article in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Influence of Single Nucleotide Polymorphisms On Body Weight Trajectory After Bariatric Surgery: A Systematic Review.Current obesity reports · 2023Pooled it
- Genetic and physiological insights into satiation variability predict responses to obesity treatment.Cell metabolism · 2025Trial
- The AP-2 Family of Transcription Factors-Still Undervalued Regulators in Gastroenterological Disorders.International journal of molecular sciences · 2024Review
- MTCH2 in Metabolic Diseases, Neurodegenerative Diseases, Cancers, Embryonic Development and Reproduction.Drug design, development and therapy · 2024Review
- Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery.Journal of clinical medicine · 2023Article
- Parental Obesity Predisposition and Age of Onset Associate with Poor Response to Bariatric and Metabolic Surgery.Obesity surgery · 2023Article
- Changes in Eating Behaviors and Their Associations with Weight Loss in Japanese Patients Who Underwent Laparoscopic Sleeve Gastrectomy.Nutrients · 2023Article
- Metabolic Profile and Metabolite Analyses in Extreme Weight Responders to Gastric Bypass Surgery.Metabolites · 2022Article
- A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study.Journal of personalized medicine · 2021Article
- Article
- Pre-operative Predictors of Weight Loss and Weight Regain Following Roux-en-Y Gastric Bypass Surgery: a Prospective Human Study.Obesity surgery · 2020Article
- Eroded Gastric Band: Where to Next? An Analysis of the Largest Contemporary Series.Obesity surgery · 2020Article
- Effects of Bariatric Surgery in Early- and Adult-Onset Obesity in the Prospective Controlled Swedish Obese Subjects Study.Diabetes care · 2020Article
- A Genetic Risk Score for the Estimation of Weight Loss After Bariatric Surgery.Obesity surgery · 2020Article
- Preoperative considerations for the pediatric patient undergoing metabolic and bariatric surgery.Seminars in pediatric surgery · 2020Review
- A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants.Drug development research · 2020Article
- Article
- Genetic background influences weight-loss trajectories on the mid-term after bariatric surgery.International journal of obesity (2005) · 2019Article
- Genetic Determinants of Weight Loss After Bariatric Surgery.Obesity surgery · 2019Article
- Polygenic risk score for predicting weight loss after bariatric surgery.JCI insight · 2018Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, Roux-en Y gastric bypass (RYGB) is the most efficient therapy for severe obesity. Weight loss after surgery is, however, highly variable and genetically influenced. Genome-wide association studies have identified several single nucleotide polymorphisms (SNP) associated with body mass index (BMI) and waist-hip ratio (WHR). We aimed to identify two genetic risk scores (GRS) composed of weighted BMI and WHR-associated SNPs to estimate their impact on excess BMI loss (EBMIL) after RYGB surgery.
methodsTwo hundred and thirty-eight obese patients (BMI 45.1 ± 6.2 kg/m(2), 74 % women), who underwent RYGB, were genotyped for 35 BMI and WHR-associated SNPs and were followed up after 2 years. SNPs with high impact on post-surgical weight loss were filtered out using a random forest model. The filtered SNPs were combined into a GRS and analyzed in a linear regression model.
resultsAn up to 11 % lower EBMIL with higher risk score was estimated for two GRS models (P = 0.026 resp. P = 0.021) composed of seven BMI-associated SNPs (closest genes: MC4R, TMEM160, PTBP2, NUDT3, TFAP2B, ZNF608, MAP2K5, GNPDA2, and MTCH2) and of three WHR-associated SNPs (closest genes: HOXC13, LYPLAL1, and DNM3-PIGC). Patients within the lowest GRS quartile had higher EBMIL compared to patients within the other three quartiles in both models.
conclusionsWe identified two GRSs composed of BMI and WHR-associated SNPs with significant impact on weight loss after RYGB surgery using random forest analysis as a SNP selection tool. The GRS may be useful to pre-surgically evaluate the risks for patients undergoing RYGB surgery.
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