ArticleMolecular biology and evolution2016
Recent Selection Changes in Human Genes under Long-Term Balancing Selection.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Recent Insights Into the Evolutionary Genomics of the Critically Endangered Aye-Aye (Daubentonia madagascariensis).American journal of primatology · 2025Review
- Temporal challenges in detecting balancing selection from population genomic data.G3 (Bethesda, Md.) · 2024Article
- Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2).Genes and immunity · 2023Review
- Power of neutrality tests for detecting natural selection.G3 (Bethesda, Md.) · 2023Article
- Indigenous people from Amazon show genetic signatures of pathogen-driven selection.Science advances · 2023Article
- Contrasting Patterns of Single Nucleotide Polymorphisms and Structural Variation Across Multiple Invasions.Molecular biology and evolution · 2023Article
- Inferring Balancing Selection From Genome-Scale Data.Genome biology and evolution · 2023Review
- Diverse functions associate with non-coding polymorphisms shared between humans and chimpanzees.BMC ecology and evolution · 2022Article
- Balancing selection at the human salivary agglutinin gene (iScience · 2022Article
- An atlas of CNV maps in cattle, goat and sheep.Science China. Life sciences · 2021Article
- Positive selection in admixed populations from Ethiopia.BMC genetics · 2020Article
- Evolutionary origins of genomic adaptations in an invasive copepod.Nature ecology & evolution · 2020Article
- Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6.BMC evolutionary biology · 2019Article
- Ancient polymorphisms contribute to genome-wide variation by long-term balancing selection and divergent sorting in Boechera stricta.Genome biology · 2019Article
- Article
- The Effect of Balancing Selection on Population Differentiation: A Study with HLA Genes.G3 (Bethesda, Md.) · 2018Article
- Signatures of Long-Term Balancing Selection in Human Genomes.Genome biology and evolution · 2018Article
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Authors and funding
10 authors.
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Abstract
Balancing selection is an important evolutionary force that maintains genetic and phenotypic diversity in populations. Most studies in humans have focused on long-standing balancing selection, which persists over long periods of time and is generally shared across populations. But balanced polymorphisms can also promote fast adaptation, especially when the environment changes. To better understand the role of previously balanced alleles in novel adaptations, we analyzed in detail four loci as case examples of this mechanism. These loci show hallmark signatures of long-term balancing selection in African populations, but not in Eurasian populations. The disparity between populations is due to changes in allele frequencies, with intermediate frequency alleles in Africans (likely due to balancing selection) segregating instead at low- or high-derived allele frequency in Eurasia. We explicitly tested the support for different evolutionary models with an approximate Bayesian computation approach and show that the patterns in PKDREJ, SDR39U1, and ZNF473 are best explained by recent changes in selective pressure in certain populations. Specifically, we infer that alleles previously under long-term balancing selection, or alleles linked to them, were recently targeted by positive selection in Eurasian populations. Balancing selection thus likely served as a source of functional alleles that mediated subsequent adaptations to novel environments.
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