Evidence map›Paper›PMID 26831908›Full record

ArticleGenome biology2016

CIDANE: comprehensive isoform discovery and abundance estimation.

Stefan Canzar, Sandro Andreotti, David Weese, Knut Reinert, Gunnar W Klau

Open access · goldAbstract read
In one paragraph

Article in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Review
  3. Counting pseudoalignments to novel splicing events.Bioinformatics (Oxford, England) · 2023
    Article
  4. Efficient Minimum Flow Decomposition via Integer Linear Programming.Journal of computational biology : a journal of computational molecular cell biology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Stefan CanzarCenter for Computational Biology, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sandro AndreottiDepartment of Mathematics and Computer Science, Institute of Computer Science, Freie Universität Berlin, Arnimallee 14, Berlin, 14195, Germany.
David WeeseDepartment of Mathematics and Computer Science, Institute of Computer Science, Freie Universität Berlin, Arnimallee 14, Berlin, 14195, Germany. david.weese@fu-berlin.de.
Knut ReinertDepartment of Mathematics and Computer Science, Institute of Computer Science, Freie Universität Berlin, Arnimallee 14, Berlin, 14195, Germany. knut.reinert@fu-berlin.de.
Gunnar W KlauLife Sciences, Centrum Wiskunde & Informatica (CWI), Science Park 123, Amsterdam, 1098 XG, The Netherlands. gunnar.klau@cwi.nl.
Freie Universität Berlin · DECentrum Wiskunde & Informatica · NLToyota Technological Institute at Chicago · US

Funding

Computational Methods for Genome Assembly, Transcript Assembly, and Variant DiscoveryR01HG006677 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI SALZBERG, STEVEN L. · 2011 to 2025
$10.7M
NHGRI NIH HHS R01 HG006677NHGRI NIH HHS R01-HG006677.
6 · The paper itself

Abstract

We present CIDANE, a novel framework for genome-based transcript reconstruction and quantification from RNA-seq reads. CIDANE assembles transcripts efficiently with significantly higher sensitivity and precision than existing tools. Its algorithmic core not only reconstructs transcripts ab initio, but also allows the use of the growing annotation of known splice sites, transcription start and end sites, or full-length transcripts, which are available for most model organisms. CIDANE supports the integrated analysis of RNA-seq and additional gene-boundary data and recovers splice junctions that are invisible to other methods. CIDANE is available at http://ccb.jhu.edu/software/cidane/.

Indexed as

AlgorithmsGene Expression ProfilingHigh-Throughput Nucleotide SequencingProtein IsoformsRNARNA SplicingSequence Analysis, RNASoftwareTranscriptomeProtein IsoformsRNA

Identifiers

PMID26831908
PMCPMC4734886
OpenAlexW2255292617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.