ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
MicroRNA-155-enhanced autophagy in human gastric epithelial cell in response to Helicobacter pylori.
Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Internalization ofAnnals of medicine · 2026Review
- Programmed cell death inFrontiers in cellular and infection microbiology · 2024Review
- The role of non-coding RNA in the diagnosis and treatment ofFrontiers in medicine · 2022Review
- Maintenance of gut barrier integrity after injury: Trust your gut microRNAs.Journal of leukocyte biology · 2021Review
- Decreased microRNA-155 in Behcet's disease leads to defective control of autophagy thereby stimulating excessive proinflammatory cytokine production.Arthritis research & therapy · 2021Article
- Autophagy in Gastric Mucosa: The Dual Role and Potential Therapeutic Target.BioMed research international · 2021Review
- Function of Non-coding RNA inFrontiers in molecular biosciences · 2021Review
- Paeonol suppresses the effect of ox-LDL on mice vascular endothelial cells by regulating miR-338-3p/TET2 axis in atherosclerosis.Molecular and cellular biochemistry · 2020Article
- From Gene to Protein-How Bacterial Virulence Factors Manipulate Host Gene Expression During Infection.International journal of molecular sciences · 2020Review
- Paeonol Inhibits Oxidized Low-Density Lipoprotein-Induced Vascular Endothelial Cells Autophagy by Upregulating the Expression of miRNA-30a.Frontiers in pharmacology · 2018Article
- MicroRNA mediated regulation of immunity against gram-negative bacteria.International reviews of immunology · 2017Review
- Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk.Seminars in cell & developmental biology · 2017Review
- miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial Cells.Mediators of inflammation · 2017Article
- Deregulation of MicroRNAs in Gastric Lymphomagenesis Induced in the d3Tx Mouse Model ofFrontiers in cellular and infection microbiology · 2017Article
- Bioinformatics Study of Structural Patterns in Plant MicroRNA Precursors.BioMed research international · 2017Article
- Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract.International journal of molecular sciences · 2016Review
- miRNAs reshape immunity and inflammatory responses in bacterial infection.Signal transduction and targeted therapyArticle
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Authors and funding
6 authors.
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Abstract
BACKGROUND/
aimMicroRNAs (miRNAs) are a class of small noncoding RNAs acting as posttranscriptional gene expression regulators in many physiological and pathological conditions. MiR-155 is one kind of miRNAs that plays an important role in causing various diseases. However, the precise molecular mechanism of the ectopic expression of miR-155 in Helicobacter pylori infection remains poorly understood. Autophagy has recently been identified as an effective way to control the intracellular bacterium survival. In the present study, we demonstrate a novel role of miR-155 in regulating the autophagy-mediated anti-H. pylori response. PATIENTS AND
methodsTotally 86 H. pylori-positive patients together with 10 H. pylori-negative, healthy control subjects were included in the study. Correlation between immunohistochemical grades and miR-155 expression were determined. Molecular mechanism of miR-155 on regulation of autophagy and elimination of intracellular H. pylori were determined using the GES-1 cell model.
resultsWe found that overexpression of miR-155 by transfecting miR-155 mimics could significantly decrease the survival of intracellular H. pylori, and this process was through induction of autophagy. Furthermore, there was a significant correlation between miR-155 and immunohistochemical grades in H. pylori-positive patients, and miR-155 expression were decreased in the intestinal metaplasia group.
conclusionsThe results have indicated that the miR-155 expression level plays a key role in immunity response against H. pylori and this might provide potential targets for the future treatment of H. pylori-related diseases.
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