ArticleJournal of clinical research in pediatric endocrinology2015
Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents.
Article in Journal of clinical research in pediatric endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Cardiovascular Prevention in Children, Adolescents, and Young Adults. A Call-to-Action of the Italian Societies of Pediatrics (SIP), Hypertension (SIIA), Study of Atherosclerosis (SISA), and Cardiovascular Prevention (SIPREC).High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Guideline
- Disparities in the Prevalence of Childhood Obesity-Related Comorbidities: A Systematic Review.Frontiers in public health · 2022Pooled it
- Impact of Lifestyle Intervention Programs for Children and Adolescents with Overweight or Obesity on Body Weight and Selected Cardiometabolic Factors-A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Cardiometabolic outcome of MyBFF@school intervention program among secondary schoolchildren: a cluster randomized controlled trial.BMC public health · 2026Trial
- Effects and Moderators of Exergaming on Glucose and Lipid Metabolism in Children and Adolescents: Systematic Review and Meta-Analysis.JMIR serious games · 2026Review
- Clinical utility of a novel index for predicting metabolic dysfunction-associated steatotic liver disease risk in children.European journal of pediatrics · 2026Article
- Lipid and glucose profiles in children and adolescents: associations with body composition and metabolic risk factors-a cross-sectional study.Scientific reports · 2026Article
- Uric Acid to Platelet Ratio (UAPR) and Its Link to Lipid Abnormalities: Findings from a Large Cohort Study in Saudi Arabia.Journal of clinical medicine · 2025Article
- Obesity and cardiovascular disease: Risk assessment, physical activity, and management of complications.International journal of cardiology. Cardiovascular risk and prevention · 2024Review
- Hyperlipidemia and Cardiovascular Risk in Children and Adolescents.Biomedicines · 2023Review
- Pediatric Overweight, Fatness and Risk for Dyslipidemia Are Related to Diet: A Cross-Sectional Study in 9-year-old Children.Nutrients · 2023Article
- Triglyceride glucose index, pediatric NAFLD fibrosis index, and triglyceride-to-high-density lipoprotein cholesterol ratio are the most predictive markers of the metabolically unhealthy phenotype in overweight/obese adolescent boys.Frontiers in endocrinology · 2023Article
- Changing trends of obesity and lipid profiles among Bangkok school children after comprehensive management of the bright and healthy Thai kid project.BMC public health · 2022Article
- Dyslipidemia Diagnosis and Treatment: Risk Stratification in Children and Adolescents.Journal of nutrition and metabolism · 2022Review
- Cardiovascular Diseases in Obesity: What is the Role of Magnesium?Biological trace element research · 2021Review
- Cardiovascular Risk Factors in Children with Obesity, Preventive Diagnostics and Possible Interventions.Metabolites · 2021Review
- Metabolic Derangement in Pediatric Patient with Obesity: The Role of Ketogenic Diet as Therapeutic Tool.Nutrients · 2021Review
- Prevalence of increased transaminases and its association with sex, age, and metabolic parameters in children and adolescents with obesity - a nationwide cross-sectional cohort study.BMC pediatrics · 2021Article
- Comparison of different criteria for the definition of insulin resistance and its relationship to metabolic risk in children and adolescents.Annals of pediatric endocrinology & metabolism · 2020Article
- The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents.BMC pediatrics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChildhood-onset obesity is associated with increased mortality and morbidity related to cardiovascular diseases (CVD) during adulthood. Dyslipidemia has a fundamental role in the pathogenesis of CVD. This study aimed to evaluate the prevalence of dyslipidemia and related factors among obese children and adolescents.
methodsObese patients aged between 2 and 18 years were included in the study. Serum concentrations of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), fasting glucose levels, insulin, thyroid-stimulating hormone (TSH), free thyroxine (fT4), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and liver ultrasound findings were evaluated retrospectively.
resultsAmong 823 obese patients, 353 (42.9%) met the dyslipidemia criteria: 21.7% had hypertriglyceridemia, 19.7% had low levels of HDL-C, 18.6% had hypercholesterolemia, and 13.7% had high levels of LDL-C. Older age and/or high body mass index (BMI) were related to increased prevalence of dyslipidemia. Hepatosteatosis was more common among dyslipidemic patients. The frequency of insulin resistance (IR) and of higher levels of ALT and TSH were also detected in dyslipidemic patients. Patients with both dyslipidemia and grade 2-3 hepatosteatosis had higher levels of ALT, AST and TSH and lower levels of fT4.
conclusionPrevalence of dyslipidemia is high in obese children, and hypertriglyceridemia is in the foreground. Higher levels of IR and more apparent abnormal liver function test results are observed in the context of dyslipidemia and hepatosteatosis coexistence. Metabolic and hormonal alterations related with thyroid functions may also be associated with dyslipidemia and hepatosteatosis in obese patients.
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