ArticleDigestive diseases and sciences2016
Fatigue in Patients with Chronic Hepatitis B Living in North America: Results from the Hepatitis B Research Network (HBRN).
Article in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Health-related quality of life in adults with hepatitis B in sub-Saharan Africa: the added burden of HIV co-infection.BMC infectious diseases · 2026Observational
- Adherence to antiviral treatment among people living with chronic hepatitis B: A global survey.World journal of virology · 2025Article
- A study on the effectiveness of machine learning models for hepatitis prediction.Scientific reports · 2025Article
- Direct-Acting Antiviral Drugs Reduce Fibromyalgia Symptoms in Patients with Chronic Hepatitis C.Journal of clinical medicine · 2022Article
- Chronic hepatitis D associated with worse patient-reported outcomes than chronic hepatitis B.JHEP reports : innovation in hepatology · 2021Article
- Article
- The Efficacy of Levocarnitine Treatment in Relieving Fatigue in Patients with Cirrhosis but without Overt Hepatic Encephalopathy.Internal medicine (Tokyo, Japan) · 2021Article
- Impact of clinical and sociodemographic factors on fatigue among patients with substance use disorder: a cohort study from Norway for the period 2016-2020.Substance abuse treatment, prevention, and policy · 2020Article
- A scoping review to identify and map the multidimensional domains of pain in adults with advanced liver disease.Canadian journal of pain = Revue canadienne de la douleur · 2020Article
- Patient-reported outcomes in a large North American cohort living with chronic hepatitis B virus: a cross-sectional analysis.Alimentary pharmacology & therapeutics · 2020Article
- Fatigue in chronic hepatitis B patients is significant and associates with autonomic dysfunction.Health and quality of life outcomes · 2019Article
- Risk factors associated with fatigue in chronic hepatitis B patients.Patient preference and adherence · 2019Article
- Community-based sero-prevalence of hepatitis B and C infections in South Omo Zone, Southern Ethiopia.PloS one · 2019Article
- A quantile regression approach to explain the relationship of Fatigue and Cortisol, Cytokine among Koreans with Hepatitis B.Scientific reports · 2018Article
- Health-promoting behaviors benefit the mental health of cirrhotic outpatients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Tired of Hepatitis B?Digestive diseases and sciences · 2016Article
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Abstract
backgroundFatigue is a common symptom of liver disease but not well characterized in patients with chronic hepatitis B virus (HBV).
aimsWe assessed the rate of fatigue using a validated instrument in patients with HBV and identified demographic, virologic, and clinical features associated with fatigue in a cross-sectional cohort study from the Hepatitis B Research Network.
methodsParticipants were English- and Spanish-speaking adults with chronic HBV who were not pregnant nor on treatment. Fatigue was measured using the PROMIS® Fatigue 7-item Short Form.
resultsThe sample included 948 adults: median age 42; 51 % female; 71 % Asian; 74 % college educated; 77 % employed; 41 % inactive HBV carriers; 36 % with active chronic disease; and 2 % with advanced fibrosis, defined as AST-platelet ratio index (APRI) > 1.50. Patients with chronic HBV had a mean fatigue T-score of 46.8 ± SD = 7.9, compared to a mean fatigue T-score of 50.0 ± 10 in the US general population (p < .0001). In univariate analyses, greater fatigue was associated with demographic and clinical features such as female sex, lower income, more comorbidities, higher APRI score, and poorer mental health (p < 0.05). In multivariate analysis, female sex (p < .001), poorer mental health (p < .001), APRI score (p = .005), and history of diabetes (p = .039) were the strongest independent predictors.
conclusionsThe frequency of fatigue in this large cohort of North American chronic HBV patients may be equal to or lower than that reported in the US general population. Patients with advanced fibrosis, more comorbidities, and poorer mental health report worse fatigue.
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