ArticleChinese medical journal2016
Clinical Value of Tumor Markers for Determining Cause of Pleural Effusion.
Article in Chinese medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Is neuron-specific enolase useful for diagnosing malignant pleural effusions? evidence from a validation study and meta-analysis.BMC cancer · 2017Pooled it
- A Three-Step Diagnostic Strategy for Malignant Pleural Effusions.Cancer medicine · 2026Article
- Diagnostic value of pleural fluid neuron-specific enolase for malignant pleural effusion.Journal of thoracic disease · 2025Article
- Head-to-head comparison of the diagnostic accuracy of pleural fluid, serum carcinoembryonic antigen, and their ratio for malignant pleural effusion: a systematic review and meta-analysis.Journal of thoracic disease · 2025Article
- Development and validation of a prediction model based on a nomogram for tuberculous pleural effusion.Frontiers in medicine · 2025Article
- Article
- Comparative Study of Vascular Endothelial Growth Factor in Exudative and Transudative Pleural Effusion.Tanaffos · 2022Article
- Driverless artificial intelligence framework for the identification of malignant pleural effusion.Translational oncology · 2021Article
- The value of apolipoprotein E in distinguishing benign and malignant unilateral pleural effusions.Medicine · 2020Article
- Analysis of tumor markers in pleural effusion and serum to verify the correlations between serum tumor markers and tumor size, TNM stage of lung adenocarcinoma.Cancer medicine · 2020Article
- Medical Thoracoscopy for the Management of Exudative Pleural Effusion: A Retrospective Study.Risk management and healthcare policy · 2020Article
- Identification and diagnostic value of pleural fluid periostin and serum periostin of malignant pleural effusions in patients with non-small-cell lung cancer.Journal of clinical laboratory analysis · 2019Article
- Ratio of carcinoembryonic antigen in pleural fluid and serum for the diagnosis of malignant pleural effusion.Therapeutic advances in medical oncology · 2019Article
- New Dimensional Perspectives on Differential Diagnosis of Pleural Effusion.Chinese medical journal · 2018Article
- Carcinoembryonic antigen-positive pleural effusion in early stage non-small cell lung cancer without pleural infiltration.Journal of thoracic disease · 2018Article
- Diagnostic value of tumour markers in pleural effusions.Biochemia medica · 2018Article
- Diagnostic accuracy of tumor markers for malignant pleural effusion: a derivation and validation study.Journal of thoracic disease · 2017Article
- Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion.Journal of clinical laboratory analysis · 2017Article
- Value of human epididymis secretory protein 4 in differentiating malignant from benign pleural effusion: an analysis of two cohorts.Therapeutic advances in respiratory diseaseArticle
- Diagnostic accuracy of pleural fluid to serum carcinoembryonic antigen ratio and delta value for malignant pleural effusion: findings from two cohorts.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is often challenging to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE); thoracoscopy is among the techniques with the highest diagnostic ability in this regard. However, such invasive examinations cannot be performed on the elderly, or on those in poor physical condition. The aim of this study was to explore the differential diagnostic value of carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and squamous cell carcinoma (SCC) associated antigen in patients with TPE and MPE.
methodsUsing electrochemiluminescence, we measured the concentration of tumor markers (TMs) in the pleural effusion and serum of patients with TPE (n = 35) and MPE (n = 95). We used receiver operating characteristic (ROC) curve analysis to evaluate the TMs and differentiate between TPE and MPE.
resultsThe cut-off values for each TM in serum were: CA125, 151.55 U/ml; CA199, 9.88 U/ml; CEA, 3.50 ng/ml; NSE, 13.27 ng/ml; and SCC, 0.85 ng/ml. Those in pleural fluid were: CA125, 644.30 U/ml; CA199, 12.08 U/ml; CEA, 3.35 ng/ml; NSE, 9.71 ng/ml; and SCC, 1.35 ng/ml. The cut-off values for the ratio of pleural fluid concentration to serum concentration (P/S ratio) of each TM were: CA125, 5.93; CA199, 0.80; CEA, 1.47; NSE, 0.76; and SCC, 0.90. The P/S ratio showed the highest specificity in the case of CEA (97.14%). ROC curve analysis revealed that, for all TMs, the area under the curve in pleural fluid (0.95) was significantly different from that in serum (0.85; P < 0.001).
conclusionsTMs in TPE differ significantly from those in MPE, especially when detected in pleural fluid. The combined detection of TMs can improve diagnostic sensitivity.
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