Trial reportScientific reports2016
Distinct Reward Properties are Encoded via Corticostriatal Interactions.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit.Translational psychiatry · 2019Pooled it
- Toward a cumulative science of functional integration: A meta-analysis of psychophysiological interactions.Human brain mapping · 2016Pooled it
- Mindfulness-Oriented Recovery Enhancement remediates anhedonia in chronic opioid use by enhancing neurophysiological responses during savoring of natural rewards.Psychological medicine · 2023Trial
- Trial
- α -tACS Modulates Reward-Dependent Pupil Responses and Corticostriatal Connectivity.bioRxiv : the preprint server for biology · 2026Article
- Childhood adversity and disordered eating: the mediator role of food reward drive.Frontiers in psychology · 2026Article
- Trait reward sensitivity modulates connectivity with the temporoparietal junction and Anterior Insula during strategic decision making.Biological psychology · 2024Article
- Trait Reward Sensitivity Modulates Connectivity with the Temporoparietal Junction and Anterior Insula during Strategic Decision Making.bioRxiv : the preprint server for biology · 2024Article
- Tensorial independent component analysis reveals social and reward networks associated with major depressive disorder.Human brain mapping · 2023Article
- Decision neuroscience and neuroeconomics: Recent progress and ongoing challenges.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- Independent and interacting value systems for reward and information in the human brain.eLife · 2022Article
- Dopamine D2L Receptor Deficiency Alters Neuronal Excitability and Spine Formation in Mouse Striatum.Biomedicines · 2022Article
- Neural correlates of reward processing: Functional dissociation of two components within the ventral striatum.Brain and behavior · 2021Article
- The Role of Social Reward and Corticostriatal Connectivity in Substance Use.Journal of psychiatry and brain science · 2020Article
- Worth working for: The influence of effort costs on teens' choices during a novel decision making game.Developmental cognitive neuroscience · 2019Article
- Valuation of knowledge and ignorance in mesolimbic reward circuitry.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Distributed neural representation of saliency controlled value and category during anticipation of rewards and punishments.Nature communications · 2017Article
- The integration of social influence and reward: Computational approaches and neural evidence.Cognitive, affective & behavioral neuroscience · 2017Article
- Stress and Decision Making: Effects on Valuation, Learning, and Risk-taking.Current opinion in behavioral sciences · 2017Article
- Modulation of ventral striatal activity by cognitive effort.NeuroImage · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The striatum serves as a critical brain region for reward processing. Yet, understanding the link between striatum and reward presents a challenge because rewards are composed of multiple properties. Notably, affective properties modulate emotion while informative properties help obtain future rewards. We approached this problem by emphasizing affective and informative reward properties within two independent guessing games. We found that both reward properties evoked activation within the nucleus accumbens, a subregion of the striatum. Striatal responses to informative, but not affective, reward properties predicted subsequent utilization of information for obtaining monetary reward. We hypothesized that activation of the striatum may be necessary but not sufficient to encode distinct reward properties. To investigate this possibility, we examined whether affective and informative reward properties were differentially encoded in corticostriatal interactions. Strikingly, we found that the striatum exhibited dissociable connectivity patterns with the ventrolateral prefrontal cortex, with increasing connectivity for affective reward properties and decreasing connectivity for informative reward properties. Our results demonstrate that affective and informative reward properties are encoded via corticostriatal interactions. These findings highlight how corticostriatal systems contribute to reward processing, potentially advancing models linking striatal activation to behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.