Evidence map›Paper›PMID 26831199›Full record

SynthesisNature communications2016

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Cristian Pattaro, Alexander Teumer, Mathias Gorski, Audrey Y Chu, Man Li, Vladan Mijatovic, Maija Garnaas, Adrienne Tin, Rossella Sorice, Yong Li and 247 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 344 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
344citing papers in PubMed, 18 pooled it
38.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

344 citing papers in PubMed, 18 syntheses or guidelines pooled it, 527 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Genome-Wide Association Study for eGFR in a Taiwanese Population.Clinical journal of the American Society of Nephrology : CJASN · 2022
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Article
  20. Article

284 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

257 authors at 20 institutions in 34 countries.

Cristian PattaroCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Via Galvani 31, Bolzano 39100, Italy.ORCID http://orcid.org/0000-0002-8309-094X
Alexander TeumerInterfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Loeffler-Straße 15a, Greifswald 17487, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Mathias GorskiDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany.
Audrey Y ChuPreventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, Massachusetts 02215, USA.
Man LiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
Vladan MijatovicDepartment of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, Verona 37134, Italy.
Maija GarnaasDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, New Research Building77 Avenue Louis Pasteur, Room 458, Boston, Massachusetts 02115, USA.
Adrienne TinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
Rossella SoriceInstitute of Genetics and Biophysics "Adriano Buzzati-Traverso"-CNR, Via P. Castellino 111, Napoli 80131, Italy.
Yong LiDepartment of Internal Medicine IV, University Hospital Freiburg, Berliner Allee 29, Freiburg 79110, Germany.
Daniel TaliunCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Via Galvani 31, Bolzano 39100, Italy.
Matthias OldenDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany.
Meredith FosterDivision of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, Massachusetts 02118, USA.ORCID http://orcid.org/0000-0002-3658-1375
Ming-Huei ChenDepartment of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, Massachusetts 02118, USA.
Tune H PersDivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
Andrew D JohnsonNHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.
Yi-An KoRenal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539, USA.
Christian FuchsbergerCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Via Galvani 31, Bolzano 39100, Italy.
Bamidele TayoDepartment of Public Health Sciences, Loyola Medical Center, 2160 S First Avenue, Maywood, Illinois 60153, USA.
Michael NallsLaboratory of Neurogenetics, Building 35-Porter Building, 1A1015, National Institute on Aging/NIH, Bethesda, Maryland 20892, USA.
Mary F FeitosaDivision of Statistical Genomics, Washington University School of Medicine, 4444 Forest Park Boulevard, Box 8506, St Louis, Missouri 63108, USA.
Aaron IsaacsGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
Pio d'AdamoInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo" and University of Trieste, via dell'Istria 65/1, Trieste 34137, Italy.
Adebowale AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635, USA.ORCID http://orcid.org/0000-0002-3105-3231
Aida Karina DieffenbachDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, Germany.
Alan B ZondermanLaboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, NIH Biomedical Center, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224, USA.
Ilja M NolteUnit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Peter J van der MostUnit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Alan F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
Alan R ShuldinerDepartment of Medicine, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, Maryland 21201, USA.
Alanna C MorrisonHuman Genetics Center, University of Texas Health Science Center at Houston, 1200 Pressler St Suite 453E, Houston, Texas 77030, USA.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
Albert V SmithIcelandic Heart Association, Research Institute, Holtasmari 1, Kopavogur 201, Iceland.ORCID http://orcid.org/0000-0003-1942-5845
Albert W DreisbachDivision of Nephrology, University of Mississippi, 2500 North State Street, Jackson, Mississippi 39216, USA.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstraße 12, Kiel 24105, Germany.
Andre G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, PO Box 1738, Rotterdam 3000 DR, The Netherlands.
Andres MetspaluEstonian Genome Center of University of Tartu (EGCUT), Riia 23B, Tartu 51010, Estonia.
Anke TonjesDepartment of Medicine, University of Leipzig, Liebigstraße 18, Leipzig 04103, Germany.
Antonio LupoDivision of Nephrology, Department of Medicine, University of Verona, Piazzale Aristide Stefani 1, Verona 37126, Italy.
Antonietta RobinoInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo" and University of Trieste, via dell'Istria 65/1, Trieste 34137, Italy.
Åsa JohanssonUppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University, Uppsala SE- 75108, Sweden.
Ayse DemirkanGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
Barbara KolleritsInnsbruck Medical University, Division of Genetic Epidemiology, Schoepfstraße 41, Innsbruck 6020, Austria.
Barry I FreedmanInternal Medicine Department, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053, USA.
Belen PonteNephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital, 4 rue Gabrielle-Perret-Gentil, Geneve 1211, Switzerland.
Ben A OostraDepartment of Clinical Genetics, Erasmus University Medical Center, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
Bernhard PaulweberFirst Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Müllner Hauptstraße 48, Salzburg 5020, Austria.
Bernhard K KrämerUniversity Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg, Theodor Kutzer Ufer 1-3, Mannheim 68167, Germany.
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, Maryland 21201, USA.
Brendan M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Clinical Investigations Building, Western Rd, Cork, Ireland.
Carmen A PeraltaDivision of Nephrology, University of California, San Francisco Medical School and San Francisco VA Medical Center, 4150 Clement Street, San Francisco, California 94121, USA.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
Catherine HelmerINSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635, USA.ORCID http://orcid.org/0000-0001-5759-053X
Christian M ShafferVanderbilt University School of Medicine, 2215-B Garland Avenue 1224-MRB4 (Light Hall)Nashville, Tennessee 37232, USA.
Christian MüllerUniversity Heart Center Hamburg, Clinic for general and interventional cardiology, Martinistraße 52, Hamburg 20246, Germany.
Cinzia SalaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
Aude Saint-PierreCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Via Galvani 31, Bolzano 39100, Italy.
Daniel AckermannNephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital, 4 rue Gabrielle-Perret-Gentil, Geneve 1211, Switzerland.
Daniel ShrinerCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635, USA.
Daniela RuggieroInstitute of Genetics and Biophysics "Adriano Buzzati-Traverso"-CNR, Via P. Castellino 111, Napoli 80131, Italy.
Daniela TonioloDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Daniele CusiDepartment of Health Sciences, University of Milano, Via Antonio di Rudinì 8, Milano 20142, Italy.
Darina CzamaraMax Planck Institute of Psychiatry, Kraepelinstraße 2-10, Munich 80804, Germany.
David EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstraße 12, Kiel 24105, Germany.
David S SiscovickCardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101, USA.
Douglas RuderferDivision of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany.
Elena RochtchinaWestmead Millennium Institute, Centre for Vision Research, University of Sydney, C24 Westmead Hospital, New South Wales 2145, Australia.
Elizabeth J AtkinsonDivision of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
Elizabeth G HollidayCentre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit, New Lambton New South Wales 2305, Australia.
Eric BoerwinkleHuman Genetics Center, University of Texas Health Science Center at Houston, 1200 Pressler St Suite 453E, Houston, Texas 77030, USA.
Erika SalviDepartment of Health Sciences, University of Milano, Via Antonio di Rudinì 8, Milano 20142, Italy.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Federico MurgiaInstitute of Population Genetics-CNR, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari, Italy.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus University Medical Center, PO Box 1738, Rotterdam 3000 DR, The Netherlands.
Florian ErnstInterfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Loeffler-Straße 15a, Greifswald 17487, Germany.
Florian KronenbergInnsbruck Medical University, Division of Genetic Epidemiology, Schoepfstraße 41, Innsbruck 6020, Austria.
Frank B HuDepartment of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, Massachusetts 02115, USA.
Gerjan J NavisDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands.
Gary C CurhanBrigham and Women's Hospital and Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA.
George B EhretCardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, Geneva 1205, Switzerland.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Loeffler-Straße 15a, Greifswald 17487, Germany.
Stefan CoassinInnsbruck Medical University, Division of Genetic Epidemiology, Schoepfstraße 41, Innsbruck 6020, Austria.
Gian-Andri ThunSwiss Tropical and Public Health Institute, PO Box 4002, Basel, Switzerland.
Giorgio PistisDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy.
Giovanni GambaroDivision of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University, Via Moscati 31, Rome 00168, Italy.
Giovanni MalerbaDepartment of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, Verona 37134, Italy.
Grant W MontgomeryGenetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital, Queensland 4029, Australia.
Gudny EiriksdottirIcelandic Heart Association, Research Institute, Holtasmari 1, Kopavogur 201, Iceland.
Gunnar JacobsInstitute of Epidemiology and Biobank popgen, Christian-Albrechts University, Niemannsweg 11, Kiel 24105, Germany.
Guo LiCardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101, USA.
H-Erich WichmannInstitute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg 85764, Germany.
Harry CampbellCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG Scotland, UK.
Helena SchmidtAustrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Department of Neurology, Medical University Graz, Harrachgasse 21, Graz 8010, Austria.
Henri WallaschofskiInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475, Germany.
Henry VölzkeInstitute for Community Medicine, University of Greifswald, Walther-Rathenau-Strasse 48, Greifswald 17487, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, Germany.
Heyo K KroemerInstitute of Pharmacology, University of Greifswald, Friedrich-Loeffler-Straße 23d, Greifswald 17487, Germany.
Holly KramerDepartment of Public Health Sciences, Loyola Medical Center, 2160 S First Avenue, Maywood, Illinois 60153, USA.
Honghuang LinBoston University School of Medicine, 72 East Concord Street, B-616, Boston, Massachusetts 02118, USA.
I Mateo LeachDepartment of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30.001, Groningen 9700 RB, The Netherlands.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, R1122B Level 11, Robertson Centre, Boyd Orr Building, Glasgow G12 8QQ, UK.
Idris GuessousDivision of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland.
Igor RudanCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG Scotland, UK.ORCID http://orcid.org/0000-0001-6993-6884
Inga ProkopenkoDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.ORCID http://orcid.org/0000-0003-1624-7457
Ingrid BoreckiDivision of Statistical Genomics, Washington University School of Medicine, 4444 Forest Park Boulevard, Box 8506, St Louis, Missouri 63108, USA.
Iris M HeidDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany.
Ivana KolcicCroatian Centre for Global Health, University of Split Medical School, Šoltanska 2, Split 21000, Croatia.
Ivana PersicoInstitute of Population Genetics-CNR, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari, Italy.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands.
James F WilsonCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG Scotland, UK.
Janine F FelixDepartment of Epidemiology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
Jasmin DiversDivision of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences, 2326 Medical Center Boulevard, Winston-Salem, North Carolina 27157-1063, USA.
Jean-Charles LambertINSERM U744, Institut Pasteur de Lille, 1 rue du Pr, Calmette, Lille Cédex 59019, France.
Jeanette M StaffordDivision of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences, 2326 Medical Center Boulevard, Winston-Salem, North Carolina 27157-1063, USA.
Jean-Michel GaspozDivision of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029, USA.ORCID http://orcid.org/0000-0002-3575-5468
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, 426 Thompson Street, #3456, Ann Arbor, Michigan 48104, USA.
Jie Jin WangCentre for Vision Research, Westmead Millennium Institute, University of Sydney, C24 Westmead Hospital, New South Wales 2145, Australia.
Jingzhong DingWake Forest School of Medicine, Department of Internal Medicine/Geriatrics, Medical center Boulevard, Winston-Salem, North Carolina 27157, USA.
Joel N HirschhornDivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
John AttiaDivision of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
John B WhitfieldGenetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital, Queensland 4029, Australia.
John ChalmersUniversity of Sydney, The George Institute for Global Health, Level 10, King George V Building, 83-117 Missenden Road, Camperdown, New South Wales 2050, Australia.
Jorma ViikariDepartment of Medicine, University of Turku, Turku University Hospital, PO Box 52, Turku 20521, Finland.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
Joshua C DennyVanderbilt University School of Medicine, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212, USA.
Juha KarjalainenDepartment of Genetics, University of Groningen, University Medical Centre Groningen, PO Box 72, Groningen 9700 AB, The Netherlands.
Jyotika K FernandesDivision of Endocrinology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425, USA.
Karlhans EndlichInstitute of Anatomy and Cell Biology, University of Greifswald, Friedrich-Loeffler-Straße 23c, Greifswald 17487, Germany.
Katja ButterbachDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, Germany.
Keith L KeeneCenter for Health Disparities, Department of Biology, East Carolina University, 1001 East 10th Street, N209 Howell Science Complex Mailstop 551, Greenville, North Carolina 27858, USA.
Kurt LohmanInternal Medicine Department, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053, USA.
Laura PortasInstitute of Population Genetics-CNR, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari, Italy.
Lenore J LaunerIntramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building, 3C309, 7201 Winsconsin Avenue, Bethesda, Maryland 20892-9205, USA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere 33520, Finland.
Loic YengoCNRS UMR 8199, 1 Rue du Professeur Calmette, Lille 59000, France.
Lude FrankeDepartment of Genetics, University of Groningen, University Medical Centre Groningen, PO Box 72, Groningen 9700 AB, The Netherlands.ORCID http://orcid.org/0000-0002-5159-8802
Luigi FerrucciClinical Research Branch, National Institute on Aging, 251 Bayview Blvd, Baltimore, Maryland 21250, USA.
Lynda M RosePreventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, Massachusetts 02215, USA.
Lyudmyla KedenkoFirst Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Müllner Hauptstraße 48, Salzburg 5020, Austria.
Madhumathi RaoDivision of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA.
Maksim StruchalinDepartment of Epidemiology and Biostatistics, Erasmus University Medical Center, Dr Molewaterplein, Rotterdam 50-603015 GE, The Netherlands.
Marcus E KleberMedical Clinic V, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany.
Margherita CavalieriAustrian Stroke Prevention Study, Department of Neurology, Division of Special Neurology, Medical University Graz, Auenbruggerplatz 22, Graz 8036, Austria.
Margot HaunInnsbruck Medical University, Division of Genetic Epidemiology, Schoepfstraße 41, Innsbruck 6020, Austria.
Marilyn C CornelisDepartment of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, Massachusetts 02115, USA.
Marina CiulloInstitute of Genetics and Biophysics "Adriano Buzzati-Traverso"-CNR, Via P. Castellino 111, Napoli 80131, Italy.
Mario PirastuInstitute of Population Genetics-CNR, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari, Italy.
Mariza de AndradeDivision of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
Mark A McEvoyCentre for Clinical Epidemiology and Biostatistics, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, HRMC, New South Wales 2310, Australia.
Mark WoodwardDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
Martin AdamSwiss Tropical and Public Health Institute, PO Box 4002, Basel, Switzerland.
Massimiliano CoccaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy.
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475, Germany.
Medea ImbodenSwiss Tropical and Public Health Institute, PO Box 4002, Basel, Switzerland.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany.
Menno PruijmService of Nephrology, Lausanne University Hospital, Rue du Bugnon 17, Lausanne 1005, Switzerland.
Marie MetzgerInserm UMRS 1018, CESP Team 10, Université Paris-Sud, 16 avenue Paul Vaillant Couturier, Villejuif 94807, France.
Michael StumvollDepartment of Medicine, University of Leipzig, Liebigstraße 18, Leipzig 04103, Germany.
Michele K EvansHealth Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, NIH Biomedical Center, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224, USA.
Michele M SaleCenter for Public Health Genomics, Department of Medicine (Cardiovascular Medicine), University of Virginia, PO Box 800717, Charlottesville, Virginia 22908, USA.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, University of Tampere, School of Medicine, Tampere 33521, Finland.
Mladen BobanCroatian Centre for Global Health, University of Split Medical School, Šoltanska 2, Split 21000, Croatia.
Murielle BochudUniversity Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Route de la Corniche 2, Epalinges CH-1066, Switzerland.
Myriam RheinbergerDepartment of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30.001, Groningen 9700 RB, The Netherlands.ORCID http://orcid.org/0000-0002-4303-7685
Nabila Bouatia-NajiINSERM UMR970, Paris Cardiovascular Research Center (PARCC), 56 rue Leblanc, Paris F-75015, France.
Nicholas G MartinGenetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital, Queensland 4029, Australia.
Nick HastieMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
Nicole Probst-HenschSwiss Tropical and Public Health Institute, PO Box 4002, Basel, Switzerland.
Nicole SoranzoWellcome Trust Sanger Institute, Hinxton CB10 1HH, UK.ORCID http://orcid.org/0000-0003-1095-3852
Olivier DevuystUniversity of Zurich, Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group, Winterthurerstrasse 190, Zürich 8057, Switzerland.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital, Department of Clinical Physiology, PO Box 52, Turku 20521, Finland.
Omri GottesmanThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
Ozren PolasekCroatian Centre for Global Health, University of Split Medical School, Šoltanska 2, Split 21000, Croatia.
Paolo GaspariniInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo" and University of Trieste, via dell'Istria 65/1, Trieste 34137, Italy.
Patricia B MunroeDepartment Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Paul M RidkerHarvard Medical School, 900 Commonwealth Avenue East, Boston, Massachusetts 02115, USA.
Paul MitchellCentre for Vision Research, Westmead Millennium Institute, University of Sydney, C24 Westmead Hospital, New South Wales 2145, Australia.
Paul MuntnerUniversity of Alabama at Birmingham, Department of Medicine, 1530 3rd Avenue, South Birmingham, Alabama 35294-0022, USA.
Christa MeisingerInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Johannes H SmitDepartment of Psychiatry and EMGO+ Institute, VU University Medical Center, A.J. Ernststraat 1187, Amsterdam 1081 HL, The Netherlands.
ICBP Consortium
AGEN Consortium
CARDIOGRAM
CHARGe-Heart Failure Group
ECHOGen Consortium
Peter KovacsIFB AdiposityDiseases, University of Leipzig, Liebigstraße 21, Leipzig 04103, Germany.
Philipp S WildMedical University Center Mainz, Langenbeckstraße 1, Mainz 55131, Germany.
Philippe FroguelCNRS UMR 8199, 1 Rue du Professeur Calmette, Lille 59000, France.
Rainer RettigInstitute of Physiology, University of Greifswald, Greifswald 17487, Germany.
Reedik MägiEstonian Genome Center of University of Tartu (EGCUT), Riia 23B, Tartu 51010, Estonia.
Reiner BiffarClinic for Prosthodontic Dentistry, Gerostomatology and Material Science, University of Greifswald, Rotgerberstraße 8, Greifswald 17475, Germany.
Reinhold SchmidtAustrian Stroke Prevention Study, Department of Neurology, Division of Special Neurology, Medical University Graz, Auenbruggerplatz 22, Graz 8036, Austria.
Rita P S MiddelbergGenetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital, Queensland 4029, Australia.
Robert J CarrollVanderbilt University School of Medicine, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212, USA.
Brenda W PenninxDepartment of Psychiatry and EMGO+ Institute, VU University Medical Center, A.J. Ernststraat 1187, Amsterdam 1081 HL, The Netherlands.
Rodney J ScottSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, HRMC, New South Wales 2310, Australia.
Ronit KatzKidney Research Institute, University of Washington, Box 359606, 325 9th Avenue, Seattle, Washington 98104, USA.
Sanaz SedaghatDepartment of Epidemiology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
Sarah H WildCentre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG Scotland, UK.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029, USA.
Sheila UliviInstitute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65, Trieste 34137, Italy.
Shih-Jen HwangNHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.
Stefan EnrothUppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University, Uppsala SE- 75108, Sweden.ORCID http://orcid.org/0000-0002-5056-9137
Stefan KloiberMax Planck Institute of Psychiatry, Kraepelinstraße 2-10, Munich 80804, Germany.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands.
Benedicte StengelInserm UMRS 1018, CESP Team 10, Université Paris-Sud, 16 avenue Paul Vaillant Couturier, Villejuif 94807, France.
Stephen J HancockCentre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit, New Lambton New South Wales 2305, Australia.
Stephen T TurnerDepartment of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
Sylvia E RosasRenal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539, USA.
Sylvia StrackeINSERM U744, Institut Pasteur de Lille, 1 rue du Pr, Calmette, Lille Cédex 59019, France.
Tamara B HarrisIntramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building, 3C309, 7201 Winsconsin Avenue, Bethesda, Maryland 20892-9205, USA.
Tanja ZellerUniversity Heart Center Hamburg, Clinic for general and interventional cardiology, Martinistraße 52, Hamburg 20246, Germany.
Tatijana ZemunikCroatian Centre for Global Health, University of Split Medical School, Šoltanska 2, Split 21000, Croatia.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere 33520, Finland.
Thomas IlligInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Thor AspelundIcelandic Heart Association, Research Institute, Holtasmari 1, Kopavogur 201, Iceland.
Tiit NikopensiusEstonian Genome Center of University of Tartu (EGCUT), Riia 23B, Tartu 51010, Estonia.
Tonu EskoDivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
Toshiko TanakaClinical Research Branch, National Institute on Aging, 251 Bayview Blvd, Baltimore, Maryland 21250, USA.
Ulf GyllenstenUppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University, Uppsala SE- 75108, Sweden.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Loeffler-Straße 15a, Greifswald 17487, Germany.
Valur EmilssonIcelandic Heart Association, Research Institute, Holtasmari 1, Kopavogur 201, Iceland.
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
Ville AaltoDepartment of Clinical Physiology, Turku University Hospital, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, PO Box 52, Turku 20521, Finland.
Vilmundur GudnasonIcelandic Heart Association, Research Institute, Holtasmari 1, Kopavogur 201, Iceland.
Vincent ChourakiINSERM U744, Institut Pasteur de Lille, 1 rue du Pr, Calmette, Lille Cédex 59019, France.
Wei-Min ChenCenter for Public Health Genomics, Department of Medicine (Cardiovascular Medicine), University of Virginia, PO Box 800717, Charlottesville, Virginia 22908, USA.
Wilmar IglUppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University, Uppsala SE- 75108, Sweden.
Winfried MärzSynlab Academy, Synlab Services GmbH, Oberer Eselsberg 45, Ulm 89081, Germany.
Wolfgang KoenigDepartment of Internal Medicine II-Cardiology, University of Ulm Medical Centre, Albert-Einstein-Allee 23, Ulm 89081, Germany.
Wolfgang LiebInstitute of Epidemiology and Biobank popgen, Christian-Albrechts University, Niemannsweg 11, Kiel 24105, Germany.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Yongmei LiuInternal Medicine Department, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053, USA.
Harold SniederUnit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Peter P PramstallerCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Via Galvani 31, Bolzano 39100, Italy.
Afshin ParsaUniversity of Maryland Medical School, Division of Nephrology, 685 W. Baltimore Street, MSTF 314, Baltimore, Maryland 21201, USA.
Jeffrey R O'ConnellDepartment of Medicine, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, Maryland 21201, USA.
Katalin SusztakRenal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539, USA.
Pavel HametCRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus, 900 Saint-Denis, Montreal, Québec, Canada H2X 0A9.
Johanne TremblayCRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus, 900 Saint-Denis, Montreal, Québec, Canada H2X 0A9.
Ian H de BoerKidney Research Institute, University of Washington, Box 359606, 325 9th Avenue, Seattle, Washington 98104, USA.
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany.
Wolfram GoesslingDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, New Research Building77 Avenue Louis Pasteur, Room 458, Boston, Massachusetts 02115, USA.ORCID http://orcid.org/0000-0001-9972-1569
Daniel I ChasmanPreventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, Massachusetts 02215, USA.
Anna KöttgenDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
W H Linda KaoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
Caroline S FoxNHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.
Erasmus MC · NLUniversity of Washington · USUniversity of Michigan · USHelmholtz Zentrum München · DEImperial College London · GBInserm · FRInstitute for Integrative and Experimental Genomics · DEBrigham and Women's Hospital · USJohns Hopkins University · USUniversity Medical Center Groningen · NLUniversity of Leicester · GBWake Forest University · USJohannes Gutenberg University Mainz · DENational Heart Lung and Blood Institute · USNational Institute on Aging · USMedStar Washington Hospital Center · USNational Institutes of Health · USUniversity of Maryland, Baltimore · USUppsala University · SEBroad Institute · US

Funding

Genetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5M
CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2005 to 2019
$17.3M
Clinical Research Career Development (RMI)K12RR023250 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2005 to 2009
$13.3M
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1M
Genome-wide Search for CVD Gene-Environment InteractionsU01HL072515 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2002 to 2008
$11.2M
JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
BIOCHEMICAL AND GENETIC MARKERS OF TYPE 2 DIABETES RISKR01DK058845 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, FRANK B · 2001 to 2013
$7.8M
British Heart Foundation FS/14/55/30806British Heart Foundation RG/07/008/23674British Heart Foundation RG/08/014/24067British Heart Foundation RG/13/13/30194Intramural NIH HHS Z01 HG200362Medical Research Council G0100222Medical Research Council G0401527Medical Research Council G0600237Medical Research Council G0902037Medical Research Council G1000616Medical Research Council G19/35Medical Research Council G8802774Medical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_UU_12015/1Medical Research Council MR/K006584/1Medical Research Council MR/K013351/1Medical Research Council MR/L003120/1Medical Research Council MR/N003284/1NCI NIH HHS UM1 CA182913NCRR NIH HHS K12 RR023250NHGRI NIH HHS U01 HG004399NHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL088119NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS T32 HL007024NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL084756NIA NIH HHS F31 AG044879NIA NIH HHS R01 AG018728NIA NIH HHS R01 AG033193NIDDK NIH HHS DP3 DK108220NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK058845NIDDK NIH HHS R01 DK066574NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK084350NIDDK NIH HHS R01 DK087635NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK090311NIDDK NIH HHS R01DK090311NIGMS NIH HHS U01 GM074518NIH HHS R24 OD017870NIH HHS R24OD017870NIMHD NIH HHS R01 MD009055
6 · The paper itself

Abstract

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.

Indexed as

Genetic Predisposition to DiseaseGene Expression RegulationGenome-Wide Association StudyGenotypeHumansRenal Insufficiency, Chronic

Identifiers

PMID26831199
PMCPMC4735748
OpenAlexW2411709723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.