Evidence map›Paper›PMID 26831152›Full record

ArticleVeterinary journal (London, England : 1997)2016

3D FSE Cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties.

Molly Racette, Habib Al saleh, Kenneth R Waller, Jason A Bleedorn, Ronald P McCabe, Ray Vanderby, Mark D Markel, Sabrina H Brounts, Walter F Block, Peter Muir

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary journal (London, England : 1997), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Molly RacetteComparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.
Habib Al salehDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Kenneth R WallerComparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.
Jason A BleedornComparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.
Ronald P McCabeDepartment of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Ray VanderbyDepartment of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Mark D MarkelComparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.
Sabrina H BrountsComparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.
Walter F BlockDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Peter MuirComparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA. Electronic address: peter.muir@wisc.edu.
University of Wisconsin–Madison · US

Funding

Rapid MRI Method of Assessing Joint DegenerationU01AR059514 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLOCK, WALTER F · 2010 to 2012
$704k
Research Training of Veterinary Students in WisconsinT32OD010999 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI BJORLING, DALE EDMOND · 2012 to 2012
$60k
NIAMS NIH HHS U01 AR059514NIH HHS T32 OD010999NIH HHS T32 OD 10999
6 · The paper itself

Abstract

Estimation of cranial cruciate ligament (CrCL) structural properties in client-owned dogs with incipient cruciate rupture would be advantageous. The objective of this study was to determine whether magnetic resonance imaging (MRI) measurement of normal CrCL volume in an ex-vivo canine model predicts structural properties. Stifles from eight dogs underwent 3.0 Tesla 3D MRI. CrCL volume and normalized median grayscale values were determined using 3D Fast Spin Echo (FSE) Cube and Vastly under-sampled Isotropic PRojection (VIPR)-alternative repetition time (aTR) sequences. Stifles were then mechanically tested. After joint laxity testing, CrCL structural properties were determined, including displacement at yield, yield load, load to failure, and stiffness. Yield load and load to failure (R(2)=0.56, P <0.01) were correlated with CrCL volume determined by VIPR-aTR. Yield load was also correlated with CrCL volume determined by 3D FSE Cube (R(2)=0.32, P <0.05). Structural properties were not related to median grayscale values. Joint laxity and CrCL stiffness were not related to MRI parameters, but displacement at yield load was related to CrCL volume for both sequences during testing (R(2)>0.57, P <0.005). In conclusion, 3D MRI offers a predictive method for estimating canine CrCL structural properties. 3D MRI may be useful for monitoring CrCL properties in clinical trials.

Indexed as

AnimalsAnterior Cruciate LigamentBiomechanical PhenomenaDogsImaging, Three-DimensionalMagnetic Resonance ImagingStifleCranial cruciate ligamentLigament mechanicsMagnetic resonance imaging

Identifiers

PMID26831152
PMCPMC5506841
OpenAlexW2185574539

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.