ArticleThe journal of headache and pain2015
Right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients.
Article in The journal of headache and pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Microstructural white matter alterations associated with migraine headaches: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2022Pooled it
- A meta-analysis of neuroimaging evidence for acupuncture-mediated modulation of altered central pain processing in patients with chronic pain.Frontiers in neurologyPooled it
- Clinical efficacy of the shallow puncture and more-twirling acupuncture method in migraine treatment and its effects on serum 5-HT and β-EP levels.Technology and health care : official journal of the European Society for Engineering and Medicine · 2023Trial
- Association of cognitive ability and sleep duration with headache : insights from a Chinese middle-aged and elderly population.BMC public health · 2026Article
- [Influence of Clinical and Demographic Variables on the Characteristics of Migraine Attacks].Revista de neurologia · 2025Observational
- Cognitive Reserve and Its Associations with Pain, Anxiety, and Depression in Patients with Chronic Migraine: A Retrospective Study.Journal of clinical medicine · 2025Article
- Pain-Related White-Matter Changes Following Mild Traumatic Brain Injury: A Longitudinal Diffusion Tensor Imaging Pilot Study.Diagnostics (Basel, Switzerland) · 2025Article
- White matter alterations in episodic migraine without aura patients assessed with diffusion MRI: effect of free water correction.The journal of headache and pain · 2025Article
- Review
- Chronic Pain and Comorbid Emotional Disorders: Neural Circuitry and Neuroimmunity Pathways.International journal of molecular sciences · 2025Review
- Disrupted topologic efficiency of white matter structural connectome in migraine: a graph-based connectomics study.The journal of headache and pain · 2024Article
- Causal relationships between cortical brain structural alterations and migraine subtypes: a bidirectional Mendelian randomization study of 2,347 neuroimaging phenotypes.The journal of headache and pain · 2024Article
- Pain trajectories and their associations with cognition among older adults: a 10-year cohort study from network perspective.Age and ageing · 2024Article
- Association between chronic pain and cognitive frailty among middle-aged and elderly individuals: evidence from the China Health and Retirement Longitudinal Study.Frontiers in aging neuroscience · 2024Article
- Functional MRI and Diffusion Tensor Imaging in Migraine: A Review of Migraine Functional and White Matter Microstructural Changes.Journal of central nervous system disease · 2023Review
- Viability of AMURA biomarkers from single-shell diffusion MRI in clinical studies.Frontiers in neuroscience · 2023Article
- Psychological-health correlates of physical activity and sedentary behaviour during the COVID pandemic.Mental health and physical activity · 2022Article
- Preventive treatment can reverse cognitive impairment in chronic migraine.The journal of headache and pain · 2022Article
- Decreased degree centrality values as a potential neuroimaging biomarker for migraine: A resting-state functional magnetic resonance imaging study and support vector machine analysis.Frontiers in neurology · 2022Article
- White Matter Diffusion Properties in Chronic Temporomandibular Disorders: An Exploratory Analysis.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStructural white matter abnormalities in pain-modulating, regions are present in migraine. Whether they are associated with pain chronification and with cognitive reserve is unclear.
methodsProspective, cohort, six-month study of adult patients with episodic or chronic migraine, and controls. Cognitive reserve, quality of life, impact of pain on daily living, depression and anxiety were assessed. Participants underwent a diffusion-tensor MRI to establish the integrity of white matter tracts of three regions of interest (ROIs) implicated in pain modulation, emotion, cognition and resilience (anterior insula, anterior cingulate gyrus, and uncinate fasciculus).
resultsFifty-two individuals were enrolled: 19 episodic migraine patients, 18 chronic migraine patients, and 15 controls. The analysis of the fractional anisotropy in the ROIs showed that those patients with the poorest prognosis (i.e., those with chronic migraine despite therapy at six months--long-term chronic migraneurs) had a significantly lower fractional anisotropy in the right ROIs. Participants with higher cognitive reserve also had greater fractional anisotropy in the right anterior insula and both cingulate gyri. Multivariate analysis showed a significant association between cognitive reserve, migraine frequency, and fractional anisotropy in the right-sided regions of interest.
conclusionsLong-term chronic migraine patients show abnormalities in anterior white matter tracts, particularly of the right hemisphere, involved in pain modulation emotion, cognition and resilience. Robustness in these areas is associated with a higher cognitive reserve, which in turn might result in a lower tendency to migraine chronification.
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