ArticleScientific reports2016
Short-term memory trace mediated by termination kinetics of olfactory receptor.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Receptors underlying an odorant's valence across concentrations in Drosophila larvae.The Journal of experimental biology · 2024Article
- Prolonged activation of carbon dioxide-sensitive neurons in mosquitoes.Interface focus · 2021Article
- Behavior Responses to Chemical and Optogenetic Stimuli inFrontiers in behavioral neuroscience · 2018Article
- Olfactory Mechanisms for Discovery of Odorants to Reduce Insect-Host Contact.Journal of chemical ecology · 2016Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Odorants activate receptors in the peripheral olfactory neurons, which sends information to higher brain centers where behavioral valence is determined. Movement and airflow continuously change what odor plumes an animal encounters and little is known about the effect one plume has on the detection of another. Using the simple Drosophila melanogaster larval model to study this relationship we identify an unexpected phenomenon: response to an attractant can be selectively blocked by previous exposure to some odorants that activates the same receptor. At a mechanistic level, we find that exposure to this type of odorant causes prolonged tonic responses from a receptor (Or42b), which can block subsequent detection of a strong activator of that same receptor. We identify naturally occurring odorants with prolonged tonic responses for other odorant receptors (Ors) as well, suggesting that termination-kinetics is a factor for olfactory coding mechanisms. This mechanism has implications for odor-coding in any system and for designing applications to modify odor-driven behaviors.
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