Evidence map›Paper›PMID 26830547›Full record

ArticleClinical and experimental nephrology2017

Circulating antibodies to α-enolase and phospholipase A

Yukihiro Kimura, Naoto Miura, Hanna Debiec, Hiroyuki Morita, Harutaka Yamada, Shogo Banno, Pierre Ronco, Hirokazu Imai

Open access · hybridAbstract read
In one paragraph

Article in Clinical and experimental nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. PLA2R autoantibodies, a multifaceted biomarker in nephrotic syndrome and membranous nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Pooled it
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  3. Membranous Nephropathy.Journal of clinical medicine · 2025
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  13. Utilization of Biomarkers in Lupus Nephritis.Advances in chronic kidney disease · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yukihiro KimuraDivision of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan.
Naoto MiuraDivision of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan.
Hanna DebiecINSERM UMR_S 1155, UPMC Univ-Paris 6, Assistance Publique-Hôpitaux de Paris (AP-HP), Tenon Hospital, Paris, France.
Hiroyuki MoritaDivision of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan.
Harutaka YamadaDepartment of Internal Medicine, Kawana Hospital, Nagoya, Japan.
Shogo BannoDivision of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan.
Pierre RoncoINSERM UMR_S 1155, UPMC Univ-Paris 6, Assistance Publique-Hôpitaux de Paris (AP-HP), Tenon Hospital, Paris, France.
Hirokazu ImaiDivision of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan. imaihiro@aichi-med-u.ac.jp.
Aichi Medical University · JPAssistance Publique – Hôpitaux de Paris · FRHôpital Tenon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhospholipase A

methodsWe evaluated circulating antibodies to α-enolase by a dot blotting system and PLA

resultsIn primary MN, 18 of 25 sera (72 %) showed anti-α-enolase antibody (IgG1 and IgG4, 11 pts; IgG4 alone, six pts; IgG1 alone, one pt). In secondary MN, 15 of 20 sera (75 %) contained anti-α-enolase antibody (IgG1 and IgG3, 13 pts; IgG3 alone, two pts). No circulating anti-α-enolase antibody was found in 44 collagen diseases or septic patients, 60 nephritis without MN, and 20 healthy subjects. Twelve of 25 sera (48 %) from patients with primary MN were positive for anti-PLA

conclusionsCirculating anti-α-enolase antibodies are highly present in both primary and secondary MN (about 70 %, respectively), while anti-PLA

Indexed as

AdolescentAdultAgedAutoantibodiesBiomarkersCase-Control StudiesFemaleGlomerulonephritis, MembranousHumansJapanKidney GlomerulusMaleMiddle AgedPhosphopyruvate HydrataseReceptors, Phospholipase A2Young AdultAutoantibodiesBiomarkersPhosphopyruvate HydratasePLA2R1 protein, humanReceptors, Phospholipase A2Membranous nephropathyPhospholipase A2 receptorα-Enolase

Identifiers

PMID26830547
PMCPMC5283514
OpenAlexW2253333098

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.