Evidence map›Paper›PMID 26830541›Full record

ArticleTrends in immunology2016

Humoral Fingerprinting of Immune Responses: 'Super-Resolution', High-Dimensional Serology.

William W Lau, John S Tsang

Abstract readComment
In one paragraph

Article in Trends in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

William W LauOffice of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA.
John S TsangSystems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: john.tsang@nih.gov.

Funding

Text Analytics, Machine Learning & High Performance ComputingZIHCT000200 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI JOHNSON, CALVIN A · 2009 to 2019
$25.5M
Integrative analysis and modeling of human immune responses and pathologiesZIAAI001152 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TSANG, JOHN · 2011 to 2022
$14.1M
Intramural NIH HHS Z99 AI999999Intramural NIH HHS ZIA AI001152
6 · The paper itself

Abstract

In a recent study, Chung et al. report the development of a high-dimensional approach to assess humoral responses to immune perturbation that goes beyond antibody neutralization and titers. This approach enables the identification of potentially novel correlates and mechanisms of protective immunity to HIV vaccination, thus offering a glimpse of how dense phenotyping of serological responses coupled with bioinformatics analysis could lead to much-sought-after markers of protective vaccination responses.

Indexed as

AIDS VaccinesAnimalsAntibodies, ViralHumansImmunoglobulin GAIDS VaccinesAntibodies, ViralImmunoglobulin G

Identifiers

PMID26830541
PMCPMC4955921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.