ArticleeLife2016
Dopamine regulates stimulus generalization in the human hippocampus.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Aberrant dopaminergic activity during consolidation causes age-related memory generalization in Drosophila.PLoS biology · 2026Article
- Feature identification learning both shapes and is shaped by spatial object-similarity representations.Communications psychology · 2025Article
- To Each His Own Fear: Gender-Related Association of Anxiety, Substance Use, and Eating Disorders in a Representative Birth Cohort Sample of Young Adults with Either COMT Val158Met allele.Neuropsychobiology · 2024Article
- Developmental changes in exploration resemble stochastic optimization.Nature human behaviour · 2023Article
- Perceptual Generalization of Alcohol-Related Value Characterizes Risky Drinkers.Psychological science · 2023Article
- The Enigmatic CA2: Exploring the Understudied Region of the Hippocampus and Its Involvement in Parkinson's Disease.Biomedicines · 2023Review
- The role of memory in counterfactual valuation.Journal of experimental psychology. General · 2023Article
- A neuro-computational social learning framework to facilitate transdiagnostic classification and treatment across psychiatric disorders.Neuroscience and biobehavioral reviews · 2023Review
- Hippocampal spatio-predictive cognitive maps adaptively guide reward generalization.Nature neuroscience · 2023Article
- Reward Uncertainty and Expected Value Enhance Generalization of Episodic Memory.International journal of environmental research and public health · 2022Article
- Reinforcement learning with associative or discriminative generalization across states and actions: fMRI at 3 T and 7 T.Human brain mapping · 2022Article
- The temporal context in bayesian models of interval timing: Recent advances and future directions.Behavioral neuroscience · 2022Article
- Decision neuroscience and neuroeconomics: Recent progress and ongoing challenges.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- The prefrontal cortex, pathological anxiety, and anxiety disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Aversive outcomes impact human olfactory discrimination learning and generalization.Behavioral neuroscience · 2021Article
- Ocular measures during associative learning predict recall accuracy.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2021Article
- Knockout serotonin transporter in rats moderates outcome and stimulus generalization.Translational psychiatry · 2021Article
- Reliance on Visual Input for Balance Skill Transfer in Older Adults: EEG Connectome Analysis Using Minimal Spanning Tree.Frontiers in aging neuroscience · 2021Article
- Memory guidance of value-based decision making at an abstract level of representation.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to generalize previously learned information to novel situations is fundamental for adaptive behavior. However, too wide or too narrow generalization is linked to neuropsychiatric disorders. Previous research suggests that interactions between the dopaminergic system and the hippocampus may play a role in generalization, but whether and how the degree of generalization can be modulated via these pathways is currently unknown. Here, we addressed this question in humans using pharmacology, functional magnetic resonance imaging, and computational modeling. Blocking dopamine D2-receptors (D2R) altered generalization behavior as revealed by an increased kurtosis of the generalization gradient, and a decreased width of model-derived generalization parameters. Moreover, D2R-blockade modulated similarity-based responses in the hippocampus and decreased midbrain-hippocampal connectivity, which in turn correlated with individual differences in generalization. These results suggest that dopaminergic activity in the hippocampus may relate to the degree of generalization and highlight a potential target for treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.