Trial reportScientific reports2016
Graph theoretical analysis of brain connectivity in phantom sound perception.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Musical hallucinations and their relation with epilepsy.Journal of neurology · 2019Pooled it
- The added value of auditory cortex transcranial random noise stimulation (tRNS) after bifrontal transcranial direct current stimulation (tDCS) for tinnitus.Journal of neural transmission (Vienna, Austria : 1996) · 2017Trial
- EEG microstates and dynamic functional connectivity reveal stage-specific brain networks in subjective tinnitus.iScience · 2026Article
- Tinnitus.Nature reviews. Disease primers · 2026Review
- Shared and Individual Resting-State MEG Network Signatures of Tinnitus Revealed by Holistic Graph Learning.IEEE open journal of engineering in medicine and biology · 2026Article
- Electroencephalographic Biomarkers in Tinnitus: A Narrative Review of Current Approaches and Clinical Perspectives.Brain sciences · 2025Review
- Abnormally enhanced temporal correlations of alpha oscillations across multiple timescales in tinnitus patients.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- A scoping review of tinnitus research undertaken by New Zealand researchers: Aotearoa-an international hotspot for tinnitus innovation and collaboration.Journal of the Royal Society of New Zealand · 2025Review
- Graph analysis based on SCN reveals novel neuroanatomical targets related to tinnitus distress.Frontiers in neuroscience · 2024Article
- Characteristics of brain glucose metabolism and metabolic connectivity in noise-induced hearing loss.Scientific reports · 2023Article
- EEG-based functional connectivity for tactile roughness discrimination.Cognitive neurodynamics · 2023Article
- EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training.Frontiers in neuroscience · 2023Article
- Tinnitus and the Triple Network Model: A Perspective.Clinical and experimental otorhinolaryngology · 2022Review
- Distinct brain structural-functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy.Human brain mapping · 2022Article
- Decreased brain network global efficiency after attachment memories retrieval in individuals with unresolved/disorganized attachment-related state of mind.Scientific reports · 2022Article
- Sensorineural Hearing Loss Affects Functional Connectivity of the Auditory Cortex, Parahippocampal Gyrus and Inferior Prefrontal Gyrus in Tinnitus Patients.Frontiers in neuroscience · 2022Article
- Investigating functional changes in the brain to intermittently induced auditory illusions and its relevance to chronic tinnitus.Human brain mapping · 2020Article
- Analysis of brain connectivity during nitrous oxide sedation using graph theory.Scientific reports · 2020Article
- Altered Topological Patterns of Gray Matter Networks in Tinnitus: A Graph-Theoretical-Based Study.Frontiers in neuroscience · 2020Article
- Functional connectivity and structural analysis of trial spinal cord stimulation responders in failed back surgery syndrome.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus is a phantom sound commonly thought of to be produced by the brain related to auditory deafferentation. The current study applies concepts from graph theory to investigate the differences in lagged phase functional connectivity using the average resting state EEG of 311 tinnitus patients and 256 healthy controls. The primary finding of the study was a significant increase in connectivity in beta and gamma oscillations and a significant reduction in connectivity in the lower frequencies for the tinnitus group. There also seems to be parallel processing of long-distance information between delta, theta, alpha1 and gamma frequency bands that is significantly stronger in the tinnitus group. While the network reorganizes into a more regular topology in the low frequency carrier oscillations, development of a more random topology is witnessed in the high frequency oscillations. In summary, tinnitus can be regarded as a maladaptive 'disconnection' syndrome, which tries to both stabilize into a regular topology and broadcast the presence of a deafferentation-based bottom-up prediction error as a result of a top-down prediction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.