Evidence map›Paper›PMID 26830346›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2017

Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation.

Dino P Leone, Georgia Panagiotakos, Whitney E Heavner, Pushkar Joshi, Yangu Zhao, Heiner Westphal, Susan K McConnell

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. MotomiRs: miRNAs in Motor Neuron Function and Disease.Frontiers in molecular neuroscience · 2017
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Dino P LeoneDepartment of Biology, Stanford University, Stanford, CA, USA.
Georgia PanagiotakosDepartment of Biochemistry and Biophysics, The Ely and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.
Whitney E HeavnerDepartment of Biology, Stanford University, Stanford, CA, USA.
Pushkar JoshiDepartment of Biology, Stanford University, Stanford, CA, USA.
Yangu ZhaoLaboratory of Mammalian Genes and Development, Program in Genomics of Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Heiner WestphalLaboratory of Mammalian Genes and Development, Program in Genomics of Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Susan K McConnellDepartment of Biology, Stanford University, Stanford, CA, USA.
Stanford University · USBroad Center · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institutes of Health · US

Funding

Neurogenesis and Migration in Developing Cerebral CortexR37MH051864 · NIMH · STANFORD UNIVERSITY · PI MCCONNELL, SUSAN K · 2008 to 2017
$3.8M
NIMH NIH HHS R37 MH051864
6 · The paper itself

Abstract

Although many genes that specify neocortical projection neuron subtypes have been identified, the downstream effectors that control differentiation of those subtypes remain largely unknown. Here, we demonstrate that the LIM domain-binding proteins Ldb1 and Ldb2 exhibit dynamic and inversely correlated expression patterns during cerebral cortical development. Ldb1-deficient brains display severe defects in proliferation and changes in regionalization, phenotypes resembling those of Lhx mutants. Ldb2-deficient brains, on the other hand, exhibit striking phenotypes affecting layer 5 pyramidal neurons: Immature neurons have an impaired capacity to segregate into mature callosal and subcerebral projection neurons. The analysis of Ldb2 single-mutant mice reveals a compensatory role of Ldb1 for Ldb2 during corticospinal motor neuron (CSMN) differentiation. Animals lacking both Ldb1 and Ldb2 uncover the requirement for Ldb2 during CSMN differentiation, manifested as incomplete CSMN differentiation, and ultimately leading to a failure of the corticospinal tract.

Indexed as

Cell DifferentiationAdaptor Proteins, Signal TransducingAnimalsDNA-Binding ProteinsGene Expression Regulation, DevelopmentalLIM Domain ProteinsMice, TransgenicMotor NeuronsNeurogenesisPyramidal TractsTranscription FactorsAdaptor Proteins, Signal TransducingDNA-Binding ProteinsLdb1 protein, mouseLdb2 protein, mouseLIM Domain ProteinsTranscription Factorsbrain developmentcorticospinal motor neuronsdifferentiationLdb

Identifiers

PMID26830346
PMCPMC6075546
OpenAlexW2264696137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.