Evidence map›Paper›PMID 26830306›Full record

SynthesisWorld journal of pediatrics : WJP2016

Feasibility and efficacy of gentamicin for treating neonatal sepsis in community-based settings: a systematic review.

Nishant Jaiswal, Meenu Singh, Ritika Kondel, Navjot Kaur, Kiran K Thumburu, Ajay Kumar, Harpreet Kaur, Neelima Chadha, Neeraj Gupta, Amit Agarwal and 2 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of pediatrics : WJP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Nishant JaiswalICMR Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Meenu SinghICMR Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ritika KondelDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Navjot KaurDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Kiran K ThumburuICMR Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ajay KumarICMR Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Harpreet KaurDepartment of Library, University Business School, Punjab University, Chandigarh, India.
Neelima ChadhaDr. Tulsi Das Library, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Neeraj GuptaDepartment of Pediatrics, AIIMS, Jodhpur, Rajasthan, India.
Amit AgarwalICMR Advanced Centre for Evidence Based Child Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Samir MalhotraDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Nusrat ShafiqDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. nusrat_shafiq@hotmail.com.
Post Graduate Institute of Medical Education and Research · INAll India Institute of Medical Sciences Jodhpur · INUniversity of the Punjab · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal sepsis is a leading cause of neonatal deaths in developing countries. The current recommended in-hospital treatment is parenteral ampicillin (or penicillin) and gentamicin in young infants for 10- 14 days; however, very few could access and afford. The current review is to evaluate the feasibility of gentamicin in community based settings.

methodsBoth observational and randomized controlled trials were included. Medline, Embase, Cochrane Central Register of Controlled Trials and Central Trial Register of India were searched until September 2013. We assessed the risk of bias by Cochrane Collaboration's "risk of bias" tool.

resultsTwo observational studies indicated feasibility ensuring coverage of population, decrease in case fatality rate in the group treated by community health workers. In an RCT, no significant difference was observed in the treatment failure rates [odds ratio (OR)=0.88], and the mortality in the first and second week (OR=1.53; OR=2.24) between gentamicin and ceftriaxone groups. Within the gentamicin group, the combination of penicillin and gentamicin showed a lower rate of treatment failure (OR=0.44) and mortality at second week of life (OR=0.17) as compared to the combination of gentamicin and oral cotrimoxazole.

conclusionGentamicin for the treatment of neonatal sepsis is both feasible and effective in community-based settings and can be used as an alternative to the hospitalbased care in resource compromised settings. But there was less evidence in the management of neonatal sepsis in hospitals as was seen in this review in which we included only one RCT and three observational studies.

Indexed as

Cause of DeathCommunity Health ServicesDeveloping CountriesDose-Response Relationship, DrugDrug Administration ScheduleFeasibility StudiesFemaleGentamicinsHumansIndiaInfant, NewbornMaleNeonatal SepsisObservational Studies as TopicRandomized Controlled Trials as TopicRisk AssessmentGentamicinsgentamicinneonatal sepsisneonates

Identifiers

PMID26830306
OpenAlexW2278506464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.