ArticleBMC genomics2016
Probiotic (Enterococcus faecium) induced responses of the hepatic proteome improves metabolic efficiency of broiler chickens (Gallus gallus).
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 78 citations in OpenAlex.
- Shotgun proteomic analysis of quail liver under feed deprivation and low-energy diet conditions.Veterinary and animal science · 2026Article
- Microbial community composition variation in relation to malaria infections in Junco hyemalis.PloS one · 2026Article
- Unveiling the probiotic potential of Enterococcus spp.: Mechanisms and roles in animal and human health, A comprehensive review.World journal of microbiology & biotechnology · 2025Review
- Evaluating the Effectiveness of Probiotic and Multivalent Vaccination Strategies in Mitigating Bacterial Chondronecrosis with Osteomyelitis Lameness Using a Hybrid Challenge Model.Animals : an open access journal from MDPI · 2025Article
- Effects of probiotics, prebiotics, and synbiotics on the growth performance, biochemical indexes, and gut morphometry of turkeys.Frontiers in physiology · 2025Article
- Identification of novel biomarkers of acute phase response in chickens challenged with Escherichia coli lipopolysaccharide endotoxin.BMC veterinary research · 2024Article
- Warming effects on lizard gut microbiome depend on habitat connectivity.Proceedings. Biological sciences · 2024Article
- Comparative Analysis of Gut Microbiomes in Laboratory Chinchillas, Ferrets, and Marmots: Implications for Pathogen Infection Research.Microorganisms · 2024Article
- Comparative pangenome analysis of Enterococcus faecium and Enterococcus lactis provides new insights into the adaptive evolution by horizontal gene acquisitions.BMC genomics · 2024Article
- Detection of antimicrobial resistance genes inVeterinary and animal science · 2023Article
- Chicken cecal microbiota reduces abdominal fat deposition by regulating fat metabolism.NPJ biofilms and microbiomes · 2023Article
- Gut microbiome and mycobiome in inflammatory bowel disease patients withFrontiers in cellular and infection microbiology · 2023Article
- Article
- The Effect ofLife (Basel, Switzerland) · 2022Article
- Caecal microbiota could effectively increase chicken growth performance by regulating fat metabolism.Microbial biotechnology · 2022Article
- Intestinal Mucosal Immunity-Mediated Modulation of the Gut Microbiome by Oral Delivery ofFrontiers in immunology · 2022Article
- Article
- Molecular mechanisms of growth depression in broiler chickens (Gallus Gallus domesticus) mediated by immune stress: a hepatic proteome study.Journal of animal science and biotechnology · 2021Article
- Understanding the interactions between Eimeria infection and gut microbiota, towards the control of chicken coccidiosis: a review.Parasite (Paris, France) · 2021Review
- In ovo inoculation of an Enterococcus faecium-based product to enhance broiler hatchability, live performance, and intestinal morphology.Poultry science · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe liver plays important roles in nutrient metabolism, detoxification and immunity. Enterococcus faecium (E. faecium) is a probiotic that has been shown to have positive effects on broiler production. However, its molecular effects on liver metabolism have not been characterized. This study aims to further identify the biological roles of E. faecium by characterizing the hepatic proteomic changes of broilers (Gallus gallus) fed E. faecium using two-dimensional fluorescence difference gel electrophoresis (2-D DIGE) and mass spectrometry (MS).
resultsThirty-three proteins (50 protein spots) involved in nutrient metabolism, immunity and the antioxidant system were shown to be differentially expressed in the liver of broilers fed E. faecium than from birds not fed the probiotic. The biological processes of sulphur amino acids, vitamin and cellular hormone metabolism, sulphur compound biosynthesis and protein tetramerization were enhanced in the liver of broilers fed E. faecium. However, proteins involved in calcium ion flux, cell redox homeostasis and platelet activation related to hepatic immune responses were down-regulated in broilers fed E. faecium. These results indicate that the supplementation of poultry feed with E. faecium may alter the partitioning of nutrients and promote optimal nutrient utilization.
conclusionsThis study assists in unraveling the molecular effects of the dietary probiotic, E. faecium, in the liver of broiler chickens. It shows that the probiotic improves the metabolism of nutrients and decreases inflammatory responses. Our findings extend previous knowledge of the mechanism of dietary probiotic action and provide new findings for research and future probiotic development.
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