Evidence map›Paper›PMID 26830141›Full record

ArticleMolecular psychiatry2016

Midbrain functional connectivity and ventral striatal dopamine D2-type receptors: link to impulsivity in methamphetamine users.

M Kohno, K Okita, A M Morales, C L Robertson, A C Dean, D G Ghahremani, F W Sabb, R A Rawson, M A Mandelkern, R M Bilder and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Brain connectivity changes to fast versus slow dopamine increases.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Interaction BetweenNeurology international · 2025
    Article
  9. Review
  10. Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  11. Article
  12. VTA glutamatergic projections to the nucleus accumbens suppress psychostimulant-seeking behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. The effects of early life stress on impulsivity.Neuroscience and biobehavioral reviews · 2022
    Review
  18. Article
  19. Prefrontal and striatal dopamine DBrain imaging and behavior · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

M KohnoDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
K OkitaDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
A M MoralesDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
C L RobertsonDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
A C DeanDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
D G GhahremaniDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
F W SabbDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
R A RawsonDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
M A MandelkernDepartment of Psychology, University of California Los Angeles, Los Angeles, CA, USA.
R M BilderDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
E D LondonDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
Neurobehavioral Systems · USUniversity of California, Los Angeles · USUniversity of California, Irvine · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
NEUROCHEMISTRY OF MODAFINIL-MA INTERACTION IN RAT BRAINP20DA022539 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2006 to 2009
$2.9M
Aerobic Exercise to Improve Outcomes of Treatment for Methamphetamine DependenceR01DA027633 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAWSON, RICHARD A · 2009 to 2014
$2.7M
Neural Systems, Inhibitory Control, and Methamphetamine DependenceR01DA020726 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2005 to 2008
$2.0M
Consortium for Neuropsychiatric Phenomics-Coordinating Center (1 of 8)UL1DE019580 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2008 to 2011
$1.9M
Response Inhibition and Dopamine Neurotransmission (RI) (4 of 8)RL1DA024853 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2007 to 2011
$1.7M
Neurobehavioral Predictors of Cognitive Decline in Methamphetamine DependenceK23DA027734 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEAN, ANDREW CLARK · 2010 to 2014
$842k
CYP2D6, brain structure, and cognitive function in methamphetamine dependenceR21DA034928 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEAN, ANDREW CLARK · 2013 to 2014
$424k
NCATS NIH HHS UL1 TR000124NIDA NIH HHS K23 DA027734NIDA NIH HHS P20 DA022539NIDA NIH HHS R01 DA020726NIDA NIH HHS R01 DA027633NIDA NIH HHS R21 DA034928NIDA NIH HHS RL1 DA024853NIDA NIH HHS T32 DA024635NIDCR NIH HHS UL1 DE019580
6 · The paper itself

Abstract

Stimulant use disorders are associated with deficits in striatal dopamine receptor availability, abnormalities in mesocorticolimbic resting-state functional connectivity (RSFC) and impulsivity. In methamphetamine-dependent research participants, impulsivity is correlated negatively with striatal D2-type receptor availability, and mesocorticolimbic RSFC is stronger than that in controls. The extent to which these features of methamphetamine dependence are interrelated, however, is unknown. This question was addressed in two studies. In Study 1, 19 methamphetamine-dependent and 26 healthy control subjects underwent [

Indexed as

AdultAmphetamine-Related DisordersCentral Nervous System StimulantsDopamineFemaleHumansImpulsive BehaviorMagnetic Resonance ImagingMaleMesencephalonMethamphetamineMiddle AgedPositron-Emission TomographyPrefrontal CortexReceptors, Dopamine D2Ventral StriatumCentral Nervous System StimulantsDopamineDRD2 protein, humanMethamphetamineReceptors, Dopamine D2

Identifiers

PMID26830141
PMCPMC4970974
OpenAlexW2261771927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.