ArticleAnnals of intensive care2016
An observational study of adult admissions to a medical ICU due to adverse drug events.
Article in Annals of intensive care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between age and medication-related hospital admission in adults: a systematic review and meta-analysis.International journal of clinical pharmacy · 2026Pooled it
- Adverse Drug Reactions in an Intensive Care Unit of a Secondary Care Lithuanian Hospital: A Prospective Observational Study.Healthcare (Basel, Switzerland) · 2025Article
- Economic burden of hospital admissions for adverse drug reactions in France: The IATROSTAT-ECO study.British journal of clinical pharmacology · 2025Article
- Development and psychometric evaluation of the family intensive care units syndrome inventory.Brain and behavior · 2023Review
- Hospital admissions to geriatric ward related to adverse drug events: a cross-sectional study from the Czech Republic.International journal of clinical pharmacy · 2021Article
- Antithrombotic therapy in patients with acute coronary syndrome complicated by cardiogenic shock or out-of-hospital cardiac arrest: a joint position paper from the European Society of Cardiology (ESC) Working Group on Thrombosis, in association with the Acute Cardiovascular Care Association (ACCA) and European Association of Percutaneous Cardiovascular Interventions (EAPCI).European heart journal. Cardiovascular pharmacotherapy · 2021Article
- Medication errors and drug knowledge gaps among critical-care nurses: a mixed multi-method study.BMC health services research · 2019Article
- Clinical pharmacist intervention reduces mortality in patients with acute myocardial infarction: a propensity score matched analysis.European journal of hospital pharmacy : science and practice · 2019Article
- Factors related to medication errors in the preparation and administration of intravenous medication in the hospital environment.PloS one · 2019Article
- Prevalence and predictors of potential drug-drug interactions in patients of internal medicine wards of a tertiary care hospital in India.European journal of hospital pharmacy : science and practice · 2018Article
- Potential drug-related problems detected by routine pharmaceutical interventions: safety and economic contributions made by hospital pharmacists in Japan.Journal of pharmaceutical health care and sciences · 2018Article
- Patients with preexisting psychiatric disorders admitted to ICU: a descriptive and retrospective cohort study.Annals of intensive care · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objectives of the study were to estimate the incidence of intensive care unit (ICU) admissions due to adverse drug events (ADEs), to assess preventability, severity and costs of the corresponding ADE and to determine the leading causes of preventable ADEs.
methodsAn observational study was conducted in a medical ICU of a teaching hospital from February 2013 to February 2014.
resultsA total of 743 consecutive admissions were included, and they involved 701 different patients. The included admissions were categorized into three groups (admissions due to preventable ADE, admissions due to unpreventable ADE and the control group). Among the 743 ICU admissions included during the study period, 173 (23.3 %) were due to ADE, with 102 (13.7 %) related to preventable ADE and 71 (9.6 %) to unpreventable ADE, yielding a preventability rate of ADE of 0.59 (102/173). Admissions due to unpreventable ADE concerned patients with more comorbidities, a greater number of drugs and higher Simplified Acute Physiology Score II than admissions due to preventable ADE and the control group admissions (n = 570). Hospital mortality rates, corresponding costs and length of stay were all similar in the preventable ADE and control groups, whereas they were always significantly higher in the unpreventable ADE group. ICU mortality, length of stay and the corresponding costs were similar in the three groups. Non-compliance was the principal leading cause of preventable ADE (n = 31/102). The 102 preventable ADE-related admissions accounted for a total of 528 days of hospitalization in the ICU, requiring a mean of 1.4 ICU beds per day over the one-year period, with an associated total cost amounting to 747,651 €.
conclusionsADE was a major cause of admission in the studied ICU, and in 59 % of the cases, ADEs were preventable. The reported burden of ICU admissions due to ADE advocates for further investigations to explore how the rate of such admissions could be decreased.
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