Evidence map›Paper›PMID 26830098›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2016

Influence of exercise training on proangiogenic TIE-2 monocytes and circulating angiogenic cells in patients with peripheral arterial disease.

Jörn F Dopheide, Philipp Geissler, Jennifer Rubrech, Amelie Trumpp, Geraldine C Zeller, Andreas Daiber, Thomas Münzel, Markus P Radsak, Christine Espinola-Klein

Abstract readComparative StudyControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
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  9. Article
  10. Environmental Pollution and Peripheral Artery Disease.Risk management and healthcare policy · 2021
    Review
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jörn F DopheideCenter of Cardiology, University Medical Center, Johannes-Gutenberg University, Langenbeckstr Str. 1, D-55101, Mainz, Germany. dopheide@uni-mainz.de.ORCID http://orcid.org/0000-0003-3365-8338
Philipp GeisslerCenter of Cardiology, University Medical Center, Johannes-Gutenberg University, Langenbeckstr Str. 1, D-55101, Mainz, Germany.
Jennifer RubrechCenter of Cardiology, University Medical Center, Johannes-Gutenberg University, Langenbeckstr Str. 1, D-55101, Mainz, Germany.
Amelie TrumppCenter of Cardiology, University Medical Center, Johannes-Gutenberg University, Langenbeckstr Str. 1, D-55101, Mainz, Germany.
Geraldine C ZellerDepartment of Internal Medicine I, University Medical Center, Johannes-Gutenberg University, Langenbeckstr Str. 1, D-55101, Mainz, Germany.
Andreas DaiberCenter of Cardiology, University Medical Center, Johannes-Gutenberg University, Langenbeckstr Str. 1, D-55101, Mainz, Germany.
Thomas MünzelCenter of Cardiology, University Medical Center, Johannes-Gutenberg University, Langenbeckstr Str. 1, D-55101, Mainz, Germany.
Markus P RadsakDepartment of Internal Medicine III, University Medical Center, Johannes-Gutenberg University, Langenbeckstr Str. 1, D-55101, Mainz, Germany.
Christine Espinola-KleinCenter of Cardiology, University Medical Center, Johannes-Gutenberg University, Langenbeckstr Str. 1, D-55101, Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammation is the driving force in atherosclerosis. One central strategy in the treatment of peripheral arterial disease (PAD) is the promotion of angiogenesis. Here, proangiogenic Tie-2 expressing monocytes (TEM) and circulating angiogenic cells (CAC) play a crucial role. Exercise training (ET) is recommended in PAD patients at Fontaine stage II to promote angiogenesis.

methods40 patients with intermittend claudication (IC) [2 groups: supervised ET (SET) vs. non-supervised ET (nSET), each n = 20] and 20 healthy controls were included in the study. Analysis of TEM and CAC was performed from whole blood by flow-cytometry. TEM were identified via CD45, CD86, CD14, CD16 and analysed for the expression of Tie-2. CAC were identified via their expression of CD45 (CD45dim), CD34 and VEGF-R2 (CD309/KDR). Follow up was performed after mean of 7.65 ± 1.62 months.

resultsIn comparison to healthy controls, we found increased proportions of CAC (p < 0.0001) and similar TEM numbers in both ET groups. At follow-up (FU) TEM poroportions increased (p < 0.001) and CAC proportions decreased (p < 0.01), but both more significantly in SET (p < 0.001) than nSET (p = 0.01). Only in SET fibrinogen levels decreased and VEGF-A increased (both p < 0.05). Finally, we found in both ET groups a significant increase in absolute walking distance but with a higher individual increase in SET (p < 0.01). TEM and CAC proportions correlated inversely with the absolute walking distance (CAC: r = -0.296, p = 0.02; TEM: r = -0.270, p = 0.04) as well as with ABI (CAC: r = -0.394, p < 0.01; TEM: r = -0.382, p < 0.01).

conclusionsET influences the distribution of CAC and TEM proportions. nSET, although still effective in regard to an improved walking distance, is less effective in the influence of proangiogenic cells and inflammatory burden than SET. Our results indicate SET to be a more preferential exercise form, supporting the necessity to establish more SET programs.

Indexed as

Exercise TherapyExercise ToleranceNeovascularization, PhysiologicAgedBiomarkersFemaleHumansInflammation MediatorsIntermittent ClaudicationLipidsMaleMiddle AgedMonocytesPeripheral Arterial DiseasePilot ProjectsReceptor, TIE-2BiomarkersInflammation MediatorsLipidsReceptor, TIE-2Vascular Endothelial Growth Factor AVEGFA protein, humanCACExercise trainingInflammationPeripheral arterial diseaseTEM

Identifiers

PMID26830098

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.