ArticleBMC research notes2016
The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs.
Article in BMC research notes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass.Physiological reports · 2017Trial
- Rumenomics: evaluation of rumen metabolites from healthy sheep identifies differentially produced metabolites across sex, age, and weight.Animal microbiome · 2026Article
- Roles of airway and intestinal epithelia in responding to pathogens and maintaining tissue homeostasis.Frontiers in cellular and infection microbiology · 2024Review
- Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells.Molecular and cellular biochemistry · 2023Article
- Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling.Gut microbes · 2023Article
- Unravelling Effects of Rosemary (Metabolites · 2023Article
- Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling.bioRxiv : the preprint server for biology · 2023Article
- Article
- Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells.iScience · 2022Article
- The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion.Metabolites · 2022Review
- CCK and GLP-1 release in response to proteinogenic amino acids using a small intestine ex vivo model in pigs.Journal of animal science · 2022Article
- Glucose- and Bile Acid-Stimulated Secretion of Gut Hormones in the Isolated Perfused Intestine Is Not Impaired in Diet-Induced Obese Mice.Frontiers in endocrinology · 2022Article
- L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion.Frontiers in endocrinology · 2021Article
- Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors.Frontiers in endocrinology · 2021Article
- What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?Frontiers in endocrinology · 2021Review
- Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis.Molecular metabolism · 2020Article
- Teduglutide Promotes Epithelial Tight Junction Pore Function in Murine Short Bowel Syndrome to Alleviate Intestinal Insufficiency.Digestive diseases and sciences · 2020Article
- Gastrointestinally Digested Protein from the InsectNutrients · 2020Article
- Effects of supplemental xylanase on health of the small intestine in nursery pigs fed diets with corn distillers' dried grains with solubles.Journal of animal science · 2020Article
- Effects of Flavanols on Enteroendocrine Secretion.Biomolecules · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMice, rats, and pigs are the three most used animal models when studying gastrointestinal peptide hormones; however their distribution from the duodenum to the distal colon has not been characterized systematically across mice, rats and pigs. We therefore performed a comparative distribution analysis of the tissue content of the major appetite- and glucose regulatory peptides: glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon-like peptide-1 (GLP-2), oxyntomodulin/glicentin, neurotensin, and peptide YY (PYY) from the duodenum to distal colon in mice (n = 9), rats (n = 9) and pigs (n = 8), using validated radioimmunoassays.
resultsGLP-1, GLP-2 and oxyntomodulin/glicentin show similar patterns of distribution within the respective species, but for rats and pigs the highest levels were found in the distal small intestine, whereas for the mouse the highest level was found in the distal colon. In rats and pigs, neurotensin was predominantly detected in mid and lower part of the small intestine, while the mouse showed the highest levels in the distal small intestine. In contrast, the distribution of GIP was restricted to the proximal small intestine in all three species. Most surprisingly, in the pig PYY was found in large amounts in the proximal part of the small intestine whereas both rats and mice had undetectable levels until the distal small intestine.
conclusionsIn summary, the distribution patterns of extractable GIP, GLP-1, GLP-2, oxyntomodulin/glicentin, neurotensin are preserved across species whereas PYY distribution showed marked differences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.