ArticleScientific reports2016
Changes in intestinal microflora of Caenorhabditis elegans following Bacillus nematocida B16 infection.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The role ofFrontiers in microbiology · 2024Review
- Methods to extract and study the biological effects of murine gut microbiota using Caenorhabditis elegans as a screening host.PloS one · 2023Article
- Characterization of Nematicidal Activity and Nematode-Toxic Metabolites of a SoilbornePathogens (Basel, Switzerland) · 2022Article
- Article
- Molecular mechanism of the smart attack of pathogenic bacteria on nematodes.Microbial biotechnology · 2020Article
- Caenorhabditis elegans: a model to understand host-microbe interactions.Cellular and molecular life sciences : CMLS · 2020Review
- Microbiota and gut ultrastructure of Anisakis pegreffii isolated from stranded cetaceans in the Adriatic Sea.Parasites & vectors · 2019Article
- Whole-genome analysis of the colonization-resistant bacterium Phytobacter sp. SCO41Molecular biology reports · 2019Article
- Zearalenone Changes the Diversity and Composition of Caecum Microbiota in Weaned Rabbit.BioMed research international · 2018Article
- The bacterial community associated with the sheep gastrointestinal nematode parasite Haemonchus contortus.PloS one · 2018Article
- Modeling Host-Microbiome Interactions inJournal of nematology · 2017Article
- The Shift of the Intestinal Microbiome in the Innate Immunity-Deficient MutantFrontiers in microbiology · 2017Article
- The native microbiome of the nematode Caenorhabditis elegans: gateway to a new host-microbiome model.BMC biology · 2016Article
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Authors and funding
7 authors.
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Abstract
The effect of pathogenic bacteria on a host and its symbiotic microbiota is vital and widespread in the biotic world. The soil-dwelling opportunistic bacterium Bacillus nematocida B16 uses a "Trojan horse" mechanism to kill Caenorhabditis elegans. The alterations in the intestinal microflora that occur after B16 infection remain unknown. Here, we analyzed the intestinal bacteria presented in normal and infected worms. The gut microbial community experienced a complex change after B16 inoculation, as determined through marked differences in species diversity, structure, distribution and composition between uninfected and infected worms. Regardless of the worm's origin (i.e., from soil or rotten fruits), the diversity of the intestinal microbiome decreased after infection. Firmicutes increased sharply, whereas Proteobacteria, Actinobacteria, Cyanobacteria and Acidobacteria decreased to different degrees. Fusobacteria was only present 12 h post-infection. After 24 h of infection, 1228 and 1109 bacterial species were identified in the uninfected and infected groups, respectively. The shared species reached 21.97%. The infected group had a greater number of Bacillus species but a smaller number of Pediococcus, Halomonas, Escherichia and Shewanella species (P < 0.01). Therefore, this study provides the first evaluation of the alterations caused by pathogenic bacteria on symbiotic microbiota using C. elegans as the model species.
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